Product Name
Recombinant purified (P. fluorescens) low endotoxin tetani toxin C-terminal fragment (52 KDa,>95%)
Subclassification
Adjuvants for protein-based vaccines
Storage
Shipped at room temperature and it should be stored at 2-8°C. Long term storage at -20°C for up to 6 months. Avoid repeated freeze thaw cycles.
Description
Tetanus toxin is an extremely potent neurotoxin produced by the vegetative cell of Clostridium tetani in anaerobic conditions, causing tetanus. It has no known function for clostridia in the soil environment where they are normally encountered.
Large inactivated toxins such as tetanus toxoid, diphtheria toxoid and diphtheria CRM197 are used as carriers in vaccines to develop strong immune responses. Conjugate vaccines rely on these immunogenic molecules to stimulate long-lasting immunity to attached polysaccharides or peptides.
In vitro, tetanus toxin C-fragment (TTC) is an efficient mucosal adjuvant and carrier molecule for the generation of mucosal antibody responses and/or induction of systemic T-cell tolerance to linked antigens. TTC is also used for tract tracing in neurological research, taking advantage of its high affinity to GT1B gangliosides and retrograde transport.
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