ANGPTL5

ANGPTL5 Full Name

angiopoietin-like 5

ANGPTL5 Introduction

ANGPTL5, short for angiopoietin-like protein 5, is a secreted protein encoded by the ANGPTL5 gene located on human chromosome 11q22.1. It belongs to the angiopoietin-like protein family, a group of secreted factors structurally related to angiopoietins but with distinct functions in metabolism and tissue homeostasis. Unlike classic angiopoietins, ANGPTL5 is not primarily involved in angiogenesis; instead, it acts as a key regulator in lipid metabolism, energy balance, and metabolic disease progression. The protein consists of 388 amino acids with a molecular weight of approximately 44.1 kDa and is classified as a secretory protein due to its N‑terminal signal peptide.

Figure 1. Strcuture of ANGPTL5.

Tissue Expression Profile of ANGPTL5
ANGPTL5 displays a distinct tissue expression pattern, with predominant expression in adipose tissue, followed by moderate levels in the heart, ovary, testis, and skin. Early studies initially reported high cardiac expression, while more recent transcript and protein analyses highlight adipose tissue as the primary source. This expression pattern aligns with its functional role in systemic lipid and energy metabolism, as adipose tissue is central to lipid storage, fatty acid release, and endocrine signaling. Secreted ANGPTL5 enters the circulation, allowing it to act distantly on metabolic tissues such as the liver, skeletal muscle, and vascular endothelium to modulate triglyceride clearance and lipid partitioning.

Clinical and Therapeutic Perspectives of ANGPTL5
Given its strong association with dyslipidemia, obesity, and type 2 diabetes, ANGPTL5 represents a promising target for treating metabolic diseases. Strategies aimed at reducing ANGPTL5 expression or neutralizing its activity could restore LPL function, lower plasma triglycerides, improve insulin sensitivity, and mitigate cardiovascular risk factors linked to metabolic syndrome. Additionally, circulating ANGPTL5 shows potential as a clinical biomarker for early detection of pre‑diabetic states and progressive obesity. Further research into the regulatory mechanisms, receptors, and signaling pathways of ANGPTL5 will deepen our understanding of its physiology and accelerate the development of targeted therapies for metabolic and hematological disorders.

Alternate Names for ANGPTL5

ANGPTL5; angiopoietin-like 5; angiopoietin-related protein 5; angiopoietin-like protein 5;

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