Secondary VHH Antibodies

Advantages of VHH

The Fig.1 shows the structural difference between the VHH and the conventional IgG. Camelid HCAb is charactered by the absence of light chains and the lack of the CH1 in the heavy-chain, and it contains only two constant regions, CH2 and CH3, and a variable region, VHH, in each chain.

Fig. 1 Schematic diagram for the primary structure of a conventional antibody, heavy-chain antibody (HCAb), nanobody, and small, recombinant antibody.
(Tang H.; et al. Int J Mol Sci. 2023)

With a longer CDR3 region, VHH has the ability to bind to a wide range of antigen epitopes. It is also more hydrophilic and stable, and can withstand high temperatures and extreme pH conditions. VHH also shows excellent tissue penetration due to the smallest size which allows them to move freely through the tissue. In addition, VHH can be easily genetically engineered at very low cost, which undoubtedly makes VHH-related products highly commercial value.

HiResNb™ Secondary VHH Antibody Performance

Creative Diagnostics offers HiResNb™ Secondary VHH Antibodies, which have excellent stability, specificity and sensitivity, and have been verified in a variety of applications. We have conjugated the products with commonly used labels to meet the scientific needs of different customers.

Highlight Features

• Animal free manufactured: Stable recombinant expression cell lines with minimal batch-to-batch variation.
• High sensitivity and specificity: Site-specific and isotype-specific VHH with a very low background.
• Brighter signal and higher resolution: Smallest size but tolerate up to 2~4 fluorophores

HiResNb™ Secondary VHH Antibodies utilize the unique characteristics of VHH, enabling excellent performance in various applications. We provide a variety of conjugated or unconjugated VHH antibodies for your choice, please check our reagent solutions list.