Recombinant SARS-CoV-2 (COVID-19) S-ECD (B.1.1.529) [His] (DAG-WT553)

SARS-CoV-2 S-ECD (B.1.1.529), recombinant protein from insect cells

Product Overview
SARS-CoV-2 S-ECD (B.1.1.529/Omicron) was expressed in insect cells and fused a polyhistidine at the C-terminus. Mutants: A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
Target
SARS-CoV-2 spike glycoprotein
Nature
Recombinant
Tag/Conjugate
His
Alternative Names
S protein; Spike glycoprotein; S glycoprotein
Format
Lyophilized
Buffer
20mM Tris, 300mM NaCl, 10% glycerol, pH 8.0
Preservative
None
Warnings
PLEASE note that this product is intended for research use only; not for diagnostic or clinical use.
Introduction
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
Keywords
SARS-CoV-2; Coronavirus; Omicron; SARS-CoV-2 spike protein

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