Product Name
RWJ 21757 Synthetic (vaccine adjuvant)
Subclassification
Adjuvants for protein-based vaccines
Storage
Shipped at room temperature and it should be stored at 2-8°C. Long term storage at -20°C for up to 6 months. Avoid repeated freeze thaw cycles.
Description
Toll-like receptors (TLRs) are a family of highly conserved germlineencoded pattern-recognition receptors that are essential for host immune responses. TLR ligands represent a promising class of immunotherapeutics or vaccine adjuvants with the potential to generate an effective antitumor immune response. The TLR7/8 agonists have aroused interest because they not only activate antigen-presenting cells but also promote activation of T and natural killer (NK) cells. Recognition of TLR7 ligands by TLR7 leads to the overall activation and maturation of antigen-presenting cells, such as dendritic cells (DCs), and the secretion of proinflammatory cytokines and type I IFN. After recognition of TLR7 ligand, mature DCs are able to fully activate effector T cells and drive more potent immune responses.
RWJ 21757 is a Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
Formula: C13H17N5O6
Purity:>98%
Solubility: 20 mM (water); 75 mM (DMSO)
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