Product Overview
Rubella Virus Nucleoprotein is produced by recombinant expression of Rubella structural polyprotein (amino acids 1-300, NCBI accession number NP_062884.1) in HEK293 cells. It contains a C-terminal 10 amino acid glycine-serine linker followed by a 6x histidine tag.
Alternative Names
Rubella virus; RV; RuV; Rubella virus Nucleoprotein; RV NP; RuV NP; RuV Nucleoprotein
Purity
> 95 % as determined by SDS-PAGE
Buffer
20mM TRIS-HCl pH8.0, 50mM NaCl, 0.5% SDS
Introduction
Rubella virus is an enveloped, positive single-stranded RNA virus and a member of the genus Rubivirus, which belongs to the Togaviridae family. The structural proteins of Rubella virus are synthesized as a polyprotein precursor in association with the endoplasmic reticulum in the host cell. It consists of three structural proteins: a capsid protein and two membrane-spanning glycoproteins, E1 and E2, localized in the virus envelope. The polyprotein is cotranslationally cleaved by the host-cell signal peptidase and the C terminus of the capsid protein remains attached to the E2 signal peptide, which anchors this viral protein to intracellular membranes. The capsid protein, excluding the E2 signal peptide, is a 277-amino-acid residue protein that forms disulfide-linked dimers. It interacts with the RNA genome and forms the nucleocapsid, which is surrounded by a lipid membrane upon which E1 and E2 are arranged.
Keywords
Rubella virus; RV; RuV; Rubella virus Nucleoprotein; RV NP; RuV NP; RuV Nucleoprotein
Citations
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