Rheumatoid Factor (RF) control

Target

RF

Nature

Native

Format

Liquid or Lyophilized

Concentration

≥250IU/ml

Buffer

Synthetic serum

Storage

Store at -20°C

Introduction

Rheumatoid factor (RF) is the autoantibody that was first found in rheumatoid arthritis. It is defined as an antibody against the Fc portion of IgG and different RFs can recognize different parts of the IgG-Fc. RF and IgG join to form immune complexes that contribute to the disease process. Rheumatoid factor can also be a cryoglobulin (antibody that precipitates on cooling of a blood sample); it can be either type 2 (monoclonal IgM to polyclonal IgG) or type 3 (polyclonal IgM to polyclonal IgG) cryoglobulin.

Keywords

Rheumatoid factor; RF; Rheumatoid arthritis; RA; Sjögren's syndrome; SLE