Product Overview
This item requires custom production and lead time is between 4-12 weeks. We can custom produce based on your specifications.
Purity
> 85% as determined by SDS-PAGE
Format
Liquid or Lyophilized powder
Storage
Store at -20°C/-80°C upon receipt. Avoid repeated freeze-thaw cycles.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Introduction
Smallpox was an infectious disease unique to humans, caused by either of two virus variants, Variola major and Variola minor. The disease is also known by the Latin names Variola or Variola vera, which is a derivative of the Latin varius, meaning "spotted", or varus, meaning "pimple". The term "smallpox" was first used in Britain in the 15th century to distinguish variola from the "great pox" (syphilis). The last naturally occurring case of smallpox (Variola minor) was diagnosed on 26 October 1977.
Function
Decapping enzyme that remove the protective 5'-cap from both host and viral mRNAs to commit transcripts for decay by the cellular exonuclease XRN1. Preferentially targets spliced mRNAs and since all viral genes are intronless, it preferentially targets host over viral transcripts. Acceleration of the turnover of cellular transcripts promotes the shutoff of host protein synthesis and therefore diminish the magnitude of antiviral response.
Keywords
Vaccinia Virus mRNA-decapping protein OPG122; D10R; EC:3.1.3.-; VACV
Citations
Publication ()
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COA
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