Product Overview
This item requires custom production and lead time is between 4-12 weeks. We can custom produce based on your specifications.
Alternative Names
DNA gyrase subunit B; gyrB
Purity
> 85% as determined by SDS-PAGE
Format
Liquid or Lyophilized powder
Storage
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Introduction
DNA gyrase subunit B (GyrB) is a critical component of Staphylococcus aureus DNA gyrase, an essential type IIA topoisomerase that regulates DNA topology by introducing negative supercoils, resolving DNA tangles, and enabling DNA replication and transcription. This ATP-dependent enzyme comprises two subunits: GyrA (breaks/rejoins DNA) and GyrB (hydrolyzes ATP to energize supercoiling). GyrB is a prime target for novel antibiotics due to its role in bacterial viability and lower resistance prevalence compared to fluoroquinolone targets (e.g., GyrA).
Keywords
Staphylococcus aureus DNA gyrase subunit B; gyrB; EC:5.6.2.2
Citations
Publication ()
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