Molecular Weight
52.0 kDa
Alternative Names
Clumping factor A; Fibrinogen receptor A; Fibrinogen-binding protein A; clfA; SACOL0856
Purity
> 90% as determined by SDS-PAGE
Format
Liquid or Lyophilized powder
Concentration
Batch dependent - please inquire should you have specific requirements.
Buffer
Lyophilized from 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
Storage
Store at 2-8°C short term and -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
Staphylococcus aureus Clumping Factor A (ClfA) is a surface-exposed virulence protein of S. aureus, belonging to the MSCRAMM adhesin family. It mediates bacterial attachment to host tissues by binding fibrinogen via a "dock, lock, latch" mechanism, crucial for immune evasion and biofilm formation. ClfA facilitates bloodstream infections, endocarditis, and medical device colonization by enabling bacterial clumping under physiological shear stress. Its fibrinogen-binding domain (residues 221–550) is a prime target for therapeutic antibodies and vaccines against antibiotic-resistant strains, including MRSA.
Keywords
Staphylococcus aureus Clumping factor A; Fibrinogen receptor A; Fibrinogen-binding protein A; clfA; SACOL0856
Citations
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