Molecular Weight
33.3 kDa
Alternative Names
Alpha-hemolysin; Alpha-HL; Alpha-toxin; hly; hla; SAOUHSC_01121
Purity
> 85% as determined by SDS-PAGE
Format
Liquid or Lyophilized powder
Concentration
Batch dependent - please inquire should you have specific requirements.
Buffer
Tris-based buffer,50% glycerol
Storage
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Introduction
Staphylococcus aureus Alpha-Hemolysin (Hla) is a pore-forming toxin critical for the bacterium's virulence. This protein assembles into a heptameric β-barrel pore on host cell membranes, disrupting osmotic balance and causing cell lysis. It primarily targets erythrocytes, endothelial cells, and immune cells, contributing to pathologies like pneumonia, sepsis, and skin infections.
Keywords
Staphylococcus aureus Alpha-hemolysin; Alpha-HL; Alpha-toxin; hly; hla; SAOUHSC_01121
Citations
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