Product Overview
SARS-CoV-2 Spike S1 N-Terminal Domain Protein (His-Tag), Recombinant
Target
SARS-CoV-2 Spike S1 NTD
Molecular Weight
~ 40 kDa (12% Reducing SDS-PAGE).
Alternative Names
SARS-CoV-2; coronavirus; SARS-CoV-2 S1; SARS-CoV-2 spike protein; SARS-CoV-2 spike S1; SARS-CoV-2 S1 NTD
Buffer
Phosphate Buffered Saline, pH 7.4
Storage
Store at -20°C. Avoid repeated freeze/thaw cycles.
Introduction
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.
Keywords
SARS-CoV-2; coronavirus; SARS-CoV-2 S1; SARS-CoV-2 spike protein; SARS-CoV-2 spike S1; SARS-CoV-2 S1 NTD
Citations
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