Product Overview
SARS-CoV-2 Spike Protein, S1 Subunit (His-Tag), Recombinant
Target
SARS-CoV-2 Spike S1
Molecular Weight
Predicted molecular weight is about 76 kDa. Based on 12% reducing SDS-PAGE, the apparent MW is about 85 kDa (due to the glycosylation).
Alternative Names
SARS-CoV-2; coronavirus; SARS-CoV-2 S1; SARS-CoV-2 spike protein; SARS-CoV-2 spike S1
Buffer
Phosphate Buffered Saline, pH 7.4
Storage
Store at -20°C. Avoid repeated freeze/thaw cycles.
Introduction
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.
Keywords
SARS-CoV-2; coronavirus; SARS-CoV-2 S1; SARS-CoV-2 spike protein; SARS-CoV-2 spike S1
Citations
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