SARS Spike Protein [GST] (DAG534)

SARS Spike Protein [GST], recombinant protein from E. coli

Product Overview
Recombinant SARS Coronavirus antigen (38 kDa), contains a mosaic of the immunodominant regions of the middle region of the Spike protein and a GST fusion partner, was expressed in E. coli, and puried in vitro using Metal affinity chromatography techniques
Nature
Recombinant
Tag/Conjugate
GST
Molecular Weight
38 kDa
Procedure
None
Purity
> 95% pure (10% PAGE, coomassie staining). GS-4B Sepharose-Affinity Purification.
Format
Purified, Liquid
Concentration
1 mg/ml
Buffer
25mM Tris-HCl, 0.4% sarcosyl, 0.25% Triton-X100, 50% glycerol
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
The SARS coronavirus, sometimes shortened to SARS-CoV, is the virus that causes severe acute respiratory syndrome (SARS). On April 16, 2003, following the outbreak of SARS in Asia and secondary cases elsewhere in the world, the World Health Organization (WHO) issued a press release stating that the coronavirus identified by a number of laboratories was the official cause of SARS. Samples of the virus are being held in laboratories in New York, San Francisco, Manila, Hong Kong, and Toronto. protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.
Antigen Description
SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.
Keywords
SARS Spike Protein; SARS spike glycoprotein; SARS Spike Protein (Middle Region); SARS (Severe Acute Respiratory Syndrome) Spike protein, Middle region; Group IV; Nidovirales; Coronaviridae; Coronavirus; SARS coronavirus; SARS; Severe acute respiratory syn

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References


Elshabrawy, HA; Coughlin, MM; et al. Human Monoclonal Antibodies against Highly Conserved HR1 and HR2 Domains of the SARS-CoV Spike Protein Are More Broadly Neutralizing. PLOS ONE 7:-(2012).
Libraty, DH; O'Neil, KM; et al. Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection. VIROLOGY 368:317-321(2007).

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