Product Overview
Recombinant S. agalactiae Hyaluronan Lyase antigen, was expressed in E. coli. Ser259-Ile1072, with an N-terminal Met and 6-His tag (Accession # NP_688206)
Purity
> 95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage
2-8°C short term, -20°C long term
Introduction
Streptococcus agalactiae is a beta-hemolytic Gram-positive streptococcus. S. agalactiae's polysaccharide antiphagocytic capsule is its main virulence factor. The hyaluronidases (EC 3.2.1.35) are a family of enzymes that degrade hyaluronic acid. In humans, there are six associated genes, including HYAL1, HYAL2, HYAL3, and PH-20/SPAM1.
Antigen Description
The hyaluronan lyase from Streptococci agalactiae is highly specific towards hyaluronan. However, a thousand fold lower activity towards unsulfated chondroitin sulfate has also been observed. The enzyme activity is Ca2+ dependent. During digestion the enzyme moves processively along the hyaluronan chains continuously releasing disaccharide units as it travels.
Keywords
Streptococcus agalactiae Hyaluronan Lyase; Streptococcus agalactiae; Group B streptococcus; GBS; Streptococcaceae; Streptococcus; S. agalactiae; S. agalactiae Hyaluronan Lyase protein
Citations
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