Full-length cDNA coding for human PM/Scl 75 fused to a hexa-histidine purification tag. Expressed by recombinant baculovirus infection of Spodoptera Sf9 insect cells..
Target
PM/Scl 75
Nature
Recombinant
Tag/Conjugate
His
Molecular Weight
52 kDa
Alternative Names
polymyositis/scleroderma; PM/Scl; PM/Scl 75
Purity
> 80%
Format
Liquid
Buffer
20mM HEPES, 150mM NaCl, 0.02% SDS
Preservative
None
Storage
Store at -80°C. Avoid repeated freeze/thaw cycles
Introduction
The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 75 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus.
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