Recombinant Human ACE2 Protein [hFc]

Target

ACE2

Nature

Recombinant

Tag/Conjugate

Fc

Molecular Weight

110 kDa

Alternative Names

ACE2; Angiotensin I converting enzyme 2

Purity

> 95 % as determined by SDS-PAGE

Format

Lyophilized Powder

Buffer

50 mM Tris, 150 mM NaCl, Arginine, pH7.5

Preservative

None

Storage

Store at ≤-20°C

Introduction

Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses.

Keywords

ACE2; Angiotensin-converting enzyme 2; SARS