Recombinant HHV-4 p23 [His] (DAGC151)

Recombinant Human herpesvirus 4 p23 (a.a. 1-162) Protein from E. coli [His]

Product Overview
HHV-4 p23 (1-162 a.a.) immunodominant region with six histidines at C-terminus
Target
HHV-4 p23
Nature
Recombinant
Tag/Conjugate
His
Alternative Names
HHV-4 p23; HHV-4; Human herpesvirus; EBV; EBV p23
Procedure
None
Purity
>95% pure; Purity: of proteins is evaluated by SDS-PAGE
Format
Liquid
Concentration
1 mg/mL
Size
100 µg
Buffer
10 mM PBS pH 7.6, 10mM NaCl
Preservative
None
Storage
Short-term store at 4°C. Long term store at -80°C.
Ship
Wet ice
Introduction
The Epstein-Barr virus (EBV or HHV-4) is a member of the herpesvirus family. It shares common traits with the viruses that cause chickenpox, shingles, cold sores, and genital herpes. EBV is tremendously prevalent—approximately 90–95% of all adults in the United States have previously been infected with EBV. EBV is well known as the cause of infectious mononucleosis ("mono" or IM) but has also been linked to long-term risks of cancer. Like the other herpesviruses, it has the ability to go into latency in the body and remains in the cells in your immune system for life after you develop an infection.
Keywords
HHV-4 p23; HHV-4; Human herpesvirus; EBV; EBV p23

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References


MDM2's dual mRNA binding domains co-ordinate its oncogenic and tumour suppressor activities

NUCLEIC ACIDS RESEARCH

Authors: Gnanasundram, Sivakumar Vadivel; Malbert-Colas, Laurence; Chen, Sa; Fusee, Leila; Daskalogianni, Chrysoula; Muller, Petr; Salomao, Norman; Fahraeus, Robin

Cell growth requires a high level of protein synthesis and oncogenic pathways stimulate cell proliferation and ribosome biogenesis. Less is known about how cells respond to dysfunctional mRNA translation and how this feeds back into growth regulatory pathways. The Epstein-Barr virus (EBV)-encoded EBNA1 causes mRNA translation stress in cis that activates PI3K delta. This leads to the stabilization of MDM2, induces MDM2's binding to the E2F1 mRNA and promotes E2F1 translation. The MDM2 serine 166 regulates the interaction with the E2F1 mRNA and deletion of MDM2 C-terminal RING domain results in a constitutive E2F1 mRNA binding. Phosphorylation on serine 395 following DNA damage instead regulates p53 mRNA binding to its RING domain and prevents the E2F1 mRNA interaction. The p14Arf tumour suppressor binds MDM2 and in addition to preventing degradation of the p53 protein it also prevents the E2F1 mRNA interaction. The data illustrate how two MDM2 domains selectively bind specific mRNAs in response to cellular conditions to promote, or suppress, cell growth and how p14Arf coordinates MDM2's activity towards p53 and E2F1. The data also show how EBV via EBNA1-induced mRNA translation stress targets the E2F1 and the MDM2 - p53 pathway.

EBV: Encoded Binary Vector for Efficient Information Retrieval, Query Processing and Recommendation for Travel and Tourism Domain EBV for Travel and Tourism Recommendation

ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING

Authors: Vijay, Jobi; Sridhar, Rajeswari

The rise in business and electronic transactions using the web as a medium has driven the widespread use of recommendation systems across all domains. Recommendation systems generate suggestions for the travel and tourism industry, particularly hotels or services, centered on user interests and preferences. Relevant information collection, organization, processing vast quantities of string data, efficient data retrieval, and computational complexity in handling information overload are key issues to be addressed in a recommendation system. This work proposes a novel approach, using encoded bit vectors, to process information on hotel amenities and features extracted from Tripadvisor. Hotel amenities at different locations are organized and stored, based on the priority of the location, using the most significant bit and least significant bit. The amenities are prioritized dynamically thereafter, based on the location, and unique amenities accorded greater preference than the ones routinely offered at most hotels. Encoded bit vectors are utilized for information retrieval and precise hotel recommendations made, based on user interest rather than the string processing method that is ineffective where scalable data are concerned. Finally, the recommended hotels are ranked with user-centric personalized recommendations. These high-speed, efficient, and scalable algorithms are ideal for incrementally updating data. They also facilitate fast, flawless IR and query processing, along with appropriate hotel recommendations. The theoretical evaluation shows that the proposed method aids quick query processing and retrieval. The experimental assessment shows that hotels recommended by the proposed bit vector recommendation system have a higher accuracy on par with user and expert recommendations.

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