Product Name
Recombinant flagellin FlicC (TLR5 agonist, vaccine adjuvant)
Subclassification
Adjuvants for protein-based vaccines
Storage
Shipped at room temperature and it should be stored at room temp. DO NOT FREEZE. Stable for 6 months.
Recommended Usage
Intranasally (i.n.) or i.m. using a two-dose protocol (100-500 µg) rabbits.
Description
Flagellin FlicC is a recombinant flagellin protein encoded by the FlicC gene from Salmonella typhimurium. Gram-negative flagellin, a Toll-like receptor 5 (TLR5) agonist, is a potent inducer of innate immune effectors such as cytokines and nitric oxide unlike other TLR agonists, flagellin tends to produce mixed Th1 and Th2 responses rather than strongly Th1 responses. It has been demonstrated that flagellin can act as a potent adjuvant in flu vaccines. Furthermore, flagellin can also signal through the NLRC4 inflammasome The plasticity of flagellin has allowed for the generation of a range of flagellin–Ag fusion proteins that have proven to be effective vaccines in animal models.
Related vaccines: Y. pestis F1 antigen Vaccine with Flagellin (Yersinia pestis).
Formulation: 50 mg of lyophilized Flagellin FliC in 10 ml sterile endotoxin-free physiological water (NaCl 0.9%)
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