Recombinant Echovirus E13 VP1 Protein [His]

Name: Recombinant Echovirus E13 VP1 Protein [His]
SKU: DAGCF-0400
Rating: 5 (1 reviews)

Echovirus E13 VP1, recombinant from E.coli

COA

SDS

Datasheet

Summary

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

31 kDa

Alternative Names

Echovirus E13; VP1

Recommended Usage

This item requires custom production and lead time is between 4-12 weeks. We can custom produce based on your specifications.

Purity

>85%

Format

Liquid or Lyophilized powder

Buffer

Tris/PBS-based buffer

Preservative

None

Storage

Store at 2-8 °C short term and -80°C long term. It is recommended to aliquot needed volumes and store at -80°C. Avoid repeated freeze/thaw cycles.

Introduction

Echovirus is a polyphyletic group of viruses associated with enteric disease in humans. The name is derived from "enteric cytopathic human orphan virus". These viruses were originally not associated with disease, but many have since been identified as disease-causing agents. The term "echovirus" was used in the scientific names of numerous species, but all echoviruses are now recognized as strains of various species, most of which are in the family Picornaviridae.

Antigen Description

Recombinant 6xHis tagged Echovirus E13 VP1 (UniProtKB No. K4MXU1) was expressed.

Keywords

Echovirus E13;VP1

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Public health impact of the Enteroviruses and Parechoviruses

MICROBIOLOGY AUSTRALIA

Authors: Knippenberg, Ben; Ferson, Mark J.

Abstract

Enteroviruses (EV) comprise viruses originally classified on cell culture replication patterns and clinical manifestations into a number of groups: poliovirus, coxsackievirus A, coxsackievirus B and ECHOvirus. The closely related genus Parechovirus has more recently been associated with human disease. EVs are common commensals of the human gut, often found without any ill effects on the person, but are also associated with a wide range of diseases and syndromes including non-specific rash illnesses, hand, foot and mouth disease (HFMD), conjunctivitis, meningitis and encephalitis, myocarditis and polio. This results in a significant burden of disease worldwide, often due to a particular genotype of EV. An estimated 1 billion people are infected with EV every year.

Evolutionary phylogeography and transmission pattern of echovirus 14: an exploration of spatiotemporal dynamics based on the 26-year acute flaccid paralysis surveillance in Shandong, China

BMC GENOMICS

Authors: Chen, Peng; Li, Yan; Tao, Zexin; Wang, Haiyan; Lin, Xiaojuan; Liu, Yao; Wang, Suting; Zhou, Nan; Wang, Pei; Xu, Aiqiang

Abstract

Background: Echovirus 14 (E-14) causes various clinical recognized syndromes, mostly with gastrointestinal syndrome and paralysis. The current study summarized the Shandong E-14 strains isolated from a 26-year acute flaccid paralysis (AFP) surveillance, and elucidated the characterization of phylogenetic and phylogeographic relationships of E-14 worldwide. Results: As a predominant serotype circulating in AFP surveillance, phylogenetic analysis showed that E-14 exhibited both time and geographic subdivision worldwide. In order to know the evolutionary history and spatial temporal dynamics of E-14, evolutionary phylogeography was reconstructed using BEAST and SPREAD software based on the VP1 sequences. The time of the most recent common ancestor of E-14 was estimated around 85 years and evolved with 9.17 x 10(-3) substitutions/site/year. Phylogeographic analysis suggested that two regional transmissions of E-14 were mainly detected, with one located between Europe and Africa countries and the other was in the Asia-Pacific region. Conclusions: Our study investigates the molecular evolution and phylogeographic of E-14, and brings new insight to the dispersal of E-14 worldwide. Regional transmission was mainly detected and Australia may be responsible for the spread of E-14 in recent years.