EBV Nuclear Antigen (DAG670)

EBV Nuclear Antigen, recombinant protein from P. pastoris

Product Overview
This product ispurified recombinant Epstein-Barr virus nuclear antigen expressed in Pichiapastoris. This recombinant protein is truncated to 340 amino acids with the glycine-alaninerepeats removed.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Molecular Weight
35 kDa
Procedure
None
Purity
> 95%, SDS PAGE
Preservative
0.09% Sodium Azide
Storage
2-8°C short term, -20°C long term
Introduction
The Epstein-Barr virus (EBV), also called Human herpes virus 4 (HHV-4), is a virus of the herpes family (which includes Herpes simplex virus and Cytomegalovirus. On infecting the B-lymphocyte, the linear virus genome circularizes and the virus subsequently persists within the cell as an episome. The virus can execute several distinct programs of gene expression which can be broadly categorized as being lytic cycle or latent cycle. The lytic cycle or productive infection results in staged expression of a host of viral proteins with the ultimate objective of producing infectious virions. Formally, this phase of infection does not inevitably lead to lysis of the host cell as EBV virions are produced by budding from the infected cell. The latent cycle (lysogenic) programs are those that do not result in production of virions. A very limited, distinct set of viral proteins are produced during latent cycle infection. These include Epstein-Barr nuclear antigen (EBNA)-1, EBNA-2, EBNA-3A, EBNA-3B, EBNA-3C, EBNA-leader protein (EBNA-LP) and latent membrane proteins (LMP)-1, LMP-2A and LMP-2B and the Epstein-Barr encoded RNAs (EBERs).
Keywords
EBV; Epstein-Barr virus; human herpesvirus 4; HHV-4; EBNA-1; Epstein-Barr Virus Nuclear Antigen; EBV Nuclear Antigen protein; human herpesvirus 4 Nuclear Antigen; HHV-4 Nuclear Antigen; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus; Human herpesvir

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References


Martins, TB; Litwin, CM; et al. Evaluation of a multiplex fluorescent microsphere immunoassay for the determination of Epstein-Barr virus serologic status. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 129:34-41(2008).
Schetter, AJ; You, WC; et al. Association of Epstein-Barr virus antibody levels with precancerous gastric lesions in a high-risk cohort. CANCER SCIENCE 99:350-354(2008).

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