Pseudotyped VSV-SARS-CoV-2 S-ΔG-Luciferase (UK variant B.1.1.7, 20I/501Y.V1, Alpha) (COV-PSV19)

Pseudotyped VSV-SARS-CoV-2 S-ΔG-Luciferase (UK variant B.1.1.7, 20I/501Y.V1, Alpha)

Product Overview
Pseudotyped VSV-SARS-CoV-2 S-ΔG-Luciferase (UK variant B.1.1.7, 20I/501Y.V1, Alpha) encodes the antigenomic-sense (or positive-sense) RNA of a replicaton-restricted recombinant vesicular stomatitis virus (rVSV) in which the glycoprotein (G) gene has been replaced with the firefly luciferase (Fluc) reporter gene and SARS-CoV-2 spike protein (ΔH69/V70, ΔY144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) is incorporated as the membrane protein on the surface of the VSV pseudotyped virus. Because the infectivity of Pseudotyped VSV-SARS-CoV-2 S-ΔG-Luciferase is restricted to a single round of replication, the pseudotypes can be handled using BSL-2 containment practices. The pseudotype VSV particles encode luciferase together with the VSV nucleocapsid (N), phosphoprotein (P), glycoprotein (G), and large polymerase subunit (L) in their pVSV-ΔG vector. When the VSV pseudovirus infect the target cells, luciferase expression is proportional to the number of cells that were infected
Nature
Virus
Size
1 mL
Storage
Store at -80°C. Multiple freeze/thaw cycles not recommended.
When using the virus, transfer the virus from the -80 ° C refrigerator and melt it in an ice bath.
Ship
Frozen on dry ice
Warnings
Biosafety Level:    BSL-2
It is the responsibility of the principal investigator to seek Institutional Biosafety Safety Committee approval for recombinant DNA, transgenic animal or infectious agent use within their laboratory spaces and maintain an Institutional Biosafety Safety Committee approval during the time period these materials are used.

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