COC chip with a classic staggered herringbone mixing structure. In the LNP mixing section, every 6 herringbone structures form one mixing module; the full mixing region contains 18 modules and 108 herringbone mixing structures. It is suitable for LNP synthesis at medium volumes (total synthesis volume: 0.4-40 mL) and medium flow rates (total flow rate: 4-40 mL/min).