Anti-TIMP3 monoclonal antibody, clone 2E9

Antibody Isotype

IgG2a

Clone

2E9

Species Reactivity

Human

Immunogen

TIMP3 (AAH14277, 112 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

HSMRK222; Protein MIG-5; K222; Tissue inhibitor of metalloproteinases 3; K222TA2; metalloproteinase inhibitor 3; SFD; MIG-5 protein; tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy,pseudoinflammatory); TIMP-3; OTTHUMP00000028880; OTTHUMP0

Entrez Gene ID

UniProt ID

Antigen Description

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby"s fundus dystrophy.
Mouse monoclonal antibody raised against a partial recombinant TIMP3.

Pathway

Endochondral Ossification, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem