Anti-IMPDH2 Monoclonal antibody, clone 2F23-C7

Antibody Isotype

IgG1

Clone

2F23-C7

Species Reactivity

Human

Immunogen

IMPDH2 (AAH12840, 1 a.a. ~ 515 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

IMP (inosine 5"-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMPD2; IMP oxireductase 2; inosine 5" phosphate dehydrogenase 2; IMPD 2; inosine monophosphate dehydrogenase type II; inosine-5"-monophosphate dehydrogenase 2; EC

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5"-monophosphate into xanthine-5"-monophosphate, which is then converted into guanosine-5"-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Mouse monoclonal antibody raised against a full length recombinant IMPDH2.

Pathway

Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, organism-specific biosystem.