Anti-FKBP1A Monoclonal antibody, clone 2F6-B23

Antibody Isotype

IgG1

Clone

2F6-B23

Species Reactivity

Human

Immunogen

FKBP1A (AAH05147, 1 a.a. ~ 109 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

FK506 binding protein 1A, 12kDa; OTTHUMP00000029980; PKC12; PKCI2; PPIASE; FK506 binding protein12; FK506-binding protein 1A (12kD); FK506-binding protein 1; FK506-binding protein 12; 12 kDa FK506-binding protein; FK506-binding protein, T-cell, 12-kD; pro

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
Mouse monoclonal antibody raised against a full length recombinant FKBP1A.

Pathway

ALK1 pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem.