Llama anti-RNase A monoclonal antibody, clone VHHmetal targets RNase A and Ni²⁺. The supplied structural record is associated with PDB 4POU; 4POY; 4PPT.
Three engineered histidines enable distinct CDR conformations for protein versus metal recognition. 4POU is RNase A-bound, 4POY is apo, and 4PPT directly shows Ni²⁺ coordination. Preserves RNase A recognition while acquiring engineered Ni²⁺ binding. Exact substitutions and quantitative affinities were partly dependent on a related patent because complete primary tables/supplements were inaccessible. Protein and metal systems must remain separate.
Product-specific preparation, formulation, size, storage, and shipping conditions were not specified in the supplied source.
Summary
Specifications
Antibody Isotype
IgG
Clone
5QPV
Conjugate
Unconjugated
Applications
Application Notes
IA, ELISA This engineered antibody retains recognition of RNase A while gaining designed Ni²⁺-binding capability. It is used in dual-specificity engineering, metal-switch antibody development, and conformational plasticity research. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded
General Notes
Preserves RNase A recognition while acquiring engineered Ni²⁺ binding. Exact substitutions and quantitative affinities were partly dependent on a related patent because complete primary tables/supplements were inaccessible. Protein and metal systems must remain separate.
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