Mouse Anti Human Emerin (amino acids 7-15) Hybridoma [NBOFN24(3E7)]

The temporal variations of the instrumental seismicity (0.5 <= M-L <= 3.5) recorded in the Mingechevir area (Azerbaijan) between January 2010 to December 2018 and its relationship with the level variation of the water reservoir was analysed in this study. The monthly number of events was analysed by using the correlogram-based periodogram, the singular spectrum analysis (SSA) and the empirical mode decomposition (EMD), which are robust against the short size of the time series. Our results point out to the following findings: (1) quasi-annual periodicity was found in one SSA reconstructed component of the monthly number of events; (2) quasi-annual periodicity was found in one EMD intrinsic mode function of the monthly number of earthquakes. These obtained results could support in a rigorously statistical manner that the seismicity occurring in Mingechevir area could be triggered by the yearly cycle of the water level of the reservoir.

Chemokines are the large family of chemotactic cytokines that play an important role in leukocyte movement and migration stimulation. Until now, several antibody-cytokine (chemokine) fusion proteins have been investigated in clinical trials because of their ability to evoke the circulating leukocytes far from the tumor site. In this case, creating the concentration gradient regarding the chemokine is very important to recruit the circulating leukocytes with maximum performance to the tumor environment. To achieve a proper gradient, the chemokine separation from the tumor antigen-bounded antibody can be very crucial. Thus, we designed a novel linker that can be cleaved by enzymes presented around the tumor site including cathepsin B, urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMPs). Also, it can inhibit tumor progression by competing with the native substrate of key proteases in the tumor microenvironment. The proposed linker was evaluated using some bioinformatics approaches. In silico results showed that the linker is structurally stable and could be detected and cleaved using the mentioned enzymes. Communicated by Ramaswamy H. Sarma