Quantitative analysis of short- and long-distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses
JOURNAL OF ANIMAL BREEDING AND GENETICS
Authors: Negro Rama, S.; Valera, M.; Membrillo, A.; Gomez, M. D.; Sole, M.; Menendez-Buxadera, A.; Anaya, G.; Molina, A.
Abstract
The association of five candidate genes with sporting performance in young and adult Spanish Trotter horses (STHs) was performed according to a previous selection based on quantitative analysis of the trait time per kilometre (TPK). A total of 334516 records of TPK from 5958 STHs were used to estimate the estimated breeding values (EBVs) at different age groups (young and adults horses) throughout the range of distances (1600-2700m) using a bicharacter random regression model. The heritability estimated by distance ranged from 0.16 to 0.40, with a different range for the two age groups. Considering the animals with the best and the worst deregressed EBV, 321 STHs were selected for SNP genotyping in MSTN, COX4I2, PDK4, DMRT3 and CKM genes. An association analysis based on ridge and logistic regression revealed that the young trotters with genotype GG in PDK4 (p<0.05) and AA of DMRT3 (p<0.001) SNPs show the best potential in short-distance races, while those carrying the genotype AA in DMRT3 (p<0.001) and CC in CKM (p<0.05) genes seem to be the best in long-distance races. Adult trotters with genotype AA in DMRT3 also display greater speed (p<0.05) and endurance (p<0.001).
Models for B-physics anomalies
NUOVO CIMENTO C-COLLOQUIA AND COMMUNICATIONS IN PHYSICS
Authors: Buttazzo, D.
Abstract
Several different experiments show evidences of Lepton Flavour Universality violation in semi-leptonic B meson decays, both in charged and neutral currents. These anomalies can be interpreted in terms of new short-distance interactions that involve mainly the third generation of fermions. I will first discuss the present status of the anomalies, and their connection to other low- and high-energy observables, in a model-independent way, adopting an Effective Field Theory approach based on a CKM-like flavour structure. I will then extend the analysis to a few simple UV completions with different types of mediator, discussing the main issues that have to be faced in each case. A few models emerge, which look capable of accommodating both charged- and neutral-current anomalies consistently with all the experimental bounds, with associated flavour and high-pT signatures within the reach of present and future experiments.
COA
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