Immunobiology Grade

Poly(I:C) (Polyinosinic-Polycytidylic) Synthetic

  • Cat.No.
  • DADF-085
  • Product Name
  • Poly(I:C) (Polyinosinic-Polycytidylic) Synthetic
  • Subclassification
  • Immunology grade
  • Classification
  • Adjuvant
  • Storage
  • Shipped at room temperature. Long term storage at -20°C for up to 6 months. Avoid repeated freeze thaw cycles.
  • Description
  • Polyinosinic:polycytidylic acid (poly I:C) is an immunostimulant. It is used in the form of its sodium salt to simulate viral infections. Poly I:C is known to interact with toll-like receptor (TLR) 3, which is expressed in the membrane of B-cells, macrophages and dendritic cells. Poly I:C is structurally similar to double-stranded RNA, which is present in some viruses and is a "natural" stimulant of TLR3. Thus, Poly I:C can be considered a synthetic analog of doublestranded RNA and is a common tool for scientific research on the immune system Double-stranded RNA, polyriboinosinicpolyribocytidylic acid (poly IC), acts as an adjuvant that enhances adaptive immune responses.

    Poly IC induces the secretion of type I IFNs, proinflammatory cytokines, and the maturation of DC. TLR3 recognizes poly IC in the endosome and initiates signaling through Toll/IL-1R domaincontaining adaptor inducing IFN-β (TRIF). There is a TLR3- independent cytoplasmic pathway for poly IC recognition. Retinoic acid-inducible gene I (RIG-I) and melanoma differentiationassociated gene 5 (Mda5) represent a family of RNA helicases that sense viral RNA in the cytoplasm. RIG-I recognizes the 5'- triphosphate end of RNA in various RNA viruses, whereas Mda5 recognizes poly IC. RIG-I and Mda5 signaling solely depends on an adaptor, IFN-β promoter stimulator 1 (IPS-1) (MAVS/Cardif/VISA). Together, the host innate immune system employs at least two pathways for poly IC recognition
    Solubility: Soluble in water up to 10 mg/ml.
    Working concentration: 10-100 mg/mouse
  • Format
  • Lyophilized, white powder
  • CAS
  • 42424-50-0

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