Product Name
Peptidoglycan (S. aureus, vaccine adjuvant)
Subclassification
Vaccine grade-PRR Ligands-based adjuvant
Storage
Shipped at room temperature and it should be stored at 2-8°C. Long term storage at -20°C for up to 6 months. Avoid repeated freeze thaw cycles.
Recommended Usage
It is recommended to use a peptidoglycan concentration of 0.15 – 3mg/l in water or buffer and measuring at 450 nm.
Description
Most bacteria have a cell wall containing a special polymer called peptidoglycan which is major component of the cell wall in gram
positive organisms. Consists of a glycan backbone with alternating β 1-4 linked residues of N-acetyl-D-glucosamine and muramic acid.
The primary immune recognition is based on structures common among invading pathogens. Surface molecules, such as lipopolysaccharide (LPS), peptidoglycan and peptidoglycan recognition protein (PGRP), are known to elicit immune reactions ranging from cytokine release to fever. Peptidoglycan activates the Toll-like receptor 2 (TLR2), present in mammalian cells
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