Please refer to the vial lable for the specific concentration.
Buffer
Supplied in PBS
Preservative
None
Storage
Short Term: 2-8°C. Long Term: -20°C. Avoid multiple freeze-thaw cycles.
Introduction
Paromomycin is an aminoglycoside antibiotic that is effective against Gram-negative and Gram-positive bacteria (MICs = 0.08-3.9 μg/ml). It also has antiprotozoal properties and decreases the parasite burden of mice infected with the leishmanial strain L.stropica when administered at doses of 50 mg/kg and 15 mg/kg, through intramuscular or intralesional routes, respectively. Paromomycin binds to the tRNA decoding A site of the 16S ribosomal RNA in bacteria, inducing a conformational change that disrupts translation and inhibits protein synthesis.
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