Description
Pam2CSK4 is a synthetic diacylated lipopeptide (LP). Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection. LP analogues of these lipoproteins signal either through TLR2/1 or TLR2/6 heterodimers. Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells.
Also induces proliferation and activation of mouse splenic B cells. According to the current model, triacylated LP like Pam3CSK4, are recognized by TLR2/1, whereas diacylated LP, such as FSL-1, induce signaling through TLR2/6. However, it was reported that diacylated LP, such as Pam2CSK4, induce signaling in a TLR6- independent manner. This finding suggests that both the lipid and peptide part of lipoproteins take part in the specificity of recognition by TLR2 heterodimer.
Formula : C65H126N10O12S
Solubility: 1 mg/ml in 20% acetonitrile / water
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