HTLV type 1 P24 Core, recombinant protein from E. coli
Recombinant HTLV-I p24 Core
Immunoreactive with all sera of HTLV-I infected individuals.
Protein is > 95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.
1.0 mg/ml, in 50 mM Na-PO4. pH 6.0, containing 1 mM DTT and 1 mM EDTA.
2-8°C short term, -20°C long term
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).