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Zika virus, Alphavirus and Marburgvirus antigens

Zika virus (ZIKV) is a member of the virus family Flaviviridae and the genus Flavivirus. It was first identified in Uganda in 1947 in rhesus monkeys and was subsequently identified in humans in 1952 in Uganda and the United Republic of Tanzania. Prior to 2015, Zika virus outbreaks occurred in areas of Africa, Southeast Asia, and the Pacific Islands. In May 2015, the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed Zika virus infections in Brazil.
Recently the Zika outbreak has reached pandemic levels.

Common symptoms of Zika are fever, rash, joint pain, and conjunctivitis (red eyes). The illness is usually mild with symptoms lasting for several days to a week. People usually don’t get sick enough to go to the hospital, and they very rarely die of Zika.

Zika is primarily transmitted through the bite of infected Aedes mosquitoes, which also spread Chikungunya and dengue. As of February 2016, evidence shows that Zika fever in pregnant women can cause abnormal brain development in their fetuses by mother-to-child transmission, which may result in miscarriage or microcephaly. Also, a link has been established with neurologic conditions in infected adults, including Guillain–Barré syndrome.

During the first 7 days of virus infection, viral RNA can usually be identified in serum, and RT-PCR is the preferred test for Zika. Since viremia decreases over time, a negative RT-PCR collected 5-7 days after symptom onset does not exclude flavivirus infection and serologic testing should be performed. Virus-specific IgM antibodies may be detectable >4 days after onset of illness. However, there are strong cross reactivity among Zika virus, dengue viruses, and other flaviviruses IgM antibodies against which may generate false positive results. Now there is no vaccine or specific medicine to treat Zika virus infections.

Creative Diagnostics has just released Zika Virus (Uganda MR 766) NS1 protein for Zika virus research and hope to develop more efficient reagents to fight against this pandemic virus.

Meanwhile we have launched some other Alphavirus and Marburg antigens for antibody production and further immunoassay purpose. Eastern equine encephalitis virus (EEEV) and Western equine encephalitis virus (WEEV) are zoonotic alphavirus and arbovirus (arthropod-borne virus) transmitted by mosquitoes, species that feed upon the blood of both birds and mammals. Marburg virus is another zoonotic (animal borne) virus. Along with Ebola virus, it causes a severe and highly fatal hemorrhagic fever which is clinically almost indistinguishable from Ebola virus disease.

Please just click here to access further information on these unique antigens:

Zika Virus
Eastern Equine Encephalitis Virus E3E2 Protein [His]
Western Equine Encephalitis Virus E2 GP [His]
Musoke Marburg virus-like particles
Musoke Marburgvirus Glycoprotein (minus the Transmembrane Region) [HA]

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