New Products

SARS-CoV-2 Antigens and Antibodies

Creative Diagnostics now can provide a variety of antigens and antibodies of SARS-CoV-2, including SARS-CoV-2 mutant proteins, biotinylated proteins, SARS-CoV-2 antibody pairs, neutralizing antibodies and so on. These antigens and antibodies can be used for scientific research, detection of SARS-CoV-2 and specific antibodies. All of our products are produced using a standardized production process to ensure the highest quality.

Target Cat. Product Name Source Tag
 S1+S2 ECD DAGC109 Recombinant SARS-CoV-2 Spike Protein [His] HEK293 cells His
DAGC158 Recombinant SARS-CoV-2 Spike(S1+S2 ECD) Protein [His] Insect Cells His
 S1 *DAGC091 Recombinant SARS-CoV-2 Spike Protein 1 [His] HEK293 Cells His
DAGC092 Recombinant SARS-CoV-2 Spike Protein 1 [human Fc] HEK293 cells hFc
DAGC093 Recombinant SARS-CoV-2 Spike Protein 1 [mouse Fc] HEK293 cells mFc
DAGC138 Recombinant SARS-CoV-2 Spike Protein 1 HEK293 cells
DAGC157 Recombinant SARS-CoV-2 Spike 1 Protein (truncated) [His] E.coli His
DAGC194 Recombinant SARS-CoV-2 Spike S1 [His] Insect Cells His
DAGC195 Recombinant SARS-CoV-2 Spike S1 NTD [His] Insect Cells His
 RBD DAGC209 Recombinant SARS-CoV-2 Spike RBD Protein (a.a. 319-541) [His] E.coli His
DAGC089 Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [Fc] HEK293 Cells mFc
*DAGC149 Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [His] HEK293 Cells His
*DAGC173 Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [hFc] HEK293 Cells hFc
*DAGC174 Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [mFc] HEK293 Cells mFc
DAGC183 Recombinant SARS-CoV-2 Spike RBD + SD1 + SD2 [His] HEK293 Cells His
DAGC184 Recombinant SARS-CoV-2 Spike RBD + SD1 [His] HEK293 Cells His
DAGC193 Recombinant SARS-CoV-2 Spike RBD [His] Insect Cells His
DAGC249 Recombinant SARS-CoV-2 Spike RBD (CHO cells) [His] CHO cells His
 S2 DAGC153 Recombinant SARS-CoV-2 S2 Protein (S2 ECD) [His] Insect Cells His

* Highly recommended for the SARS-CoV-2 serology immunoassay development

Target Cat. Product Name Capture - Detection Host Isotype
 S CABT-CS031 SARS-CoV-2 S1 Monoclonal antibody, clone BIB112 CABT-CS031 - CABT-CS033 Humanized IgG
CABT-CS033 SARS-CoV-2 S1 Monoclonal antibody, clone BIB114 Humanized IgG
CABT-CS049 SARS-CoV-2 Spike Chimeric Monoclonal antibody, clone E113 CABT-CS049 - CABT-CS050 Chimeric IgG
CABT-CS050 SARS-CoV-2 Spike Chimeric Monoclonal antibody, clone E114 Chimeric IgG
CABT-CS141 SARS-CoV-2 Trimeric S1 Monoclonal antibody, clone C4587N CABT-CS141 - CABT-CS142* Mouse IgG1
CABT-CS142 SARS-CoV-2 Trimeric S1 Monoclonal antibody, clone C4589N Mouse IgG2b
 N CABT-CS037 SARS-CoV-2 Nucleoprotein Monoclonal antibody, clone CO10 CABT-CS037 - CABT-RM320 Humanized IgG
CABT-RM320 SARS-CoV-2 Nucleoprotein monoclonal antibody, clone 120 Rabbit IgG
CABT-CS075 SARS-CoV-2 Nucleoprotein Monoclonal antibody, clone 0659 CABT-CS075 - CABT-CS076 Mouse IgG
CABT-CS076 SARS-CoV-2 Nucleoprotein Monoclonal antibody, clone 0658 Mouse IgG
CABT-MMB1 Mouse Anti-SARS-CoV-2 NP monoclonal antibody, clone NB1 CABT-MMB1 - CABT-RMJ1* Mouse IgG
CABT-RMJ1 Rabbit anti-SARS-CoV-2 NP monoclonal antibody, clone NJ1 Rabbit IgG

*Recommended antibody pair for further development of an LFA for SARS-CoV-2 Antigen.

Cat. Product Name Host Isotype
CABT-CS064 SARS-CoV-2 Spike Neutralizing Monoclonal antibody, clone NN54 Mouse IgG
CABT-CS065 SARS-CoV-2 Spike Neutralizing Monoclonal antibody, clone NN68 Mouse IgG
CABT-CS079 SARS-CoV-2 Spike RBD Neutralizing Monoclonal antibody, clone 112 Rabbit IgG
CABT-CS033 SARS-CoV-2 S1 Monoclonal antibody, clone BIB114 Humanized IgG
CABT-CS056 SARS-CoV-2 S1 Polyclonal antibody Rabbit IgG
CABT-CS057 SARS-CoV-2 S1 Polyclonal antibody Monkey IgG
Target Cat. Product Name Type Host Isotype Application
 S CABT-CS066 SARS-CoV-2 Spike PAb PAb Rabbit IgG WB, ELISA, IHC-P, FCM, ICC/IF, IP
CABT-CS056 SARS-CoV-2 S1 Neutralizing PAb PAb Rabbit IgG ELISA, Neut
CABT-CS057 SARS-CoV-2 S1 Neutralizing PAb PAb Monkey IgG ELISA, Neut
CABT-CS031 SARS-CoV-2 S1 MAb, clone BIB112 MAb Humanized IgG ELISA
CABT-CS033 SARS-CoV-2 S1 MAb, clone BIB114 MAb Humanized IgG ELISA
CABT-CS052 SARS-CoV-2 S1 MAb, clone CT13 MAb Humanized IgG ELISA
CABT-CS053 SARS-CoV-2 S1 MAb, clone CT14 MAb Humanized IgG ELISA
CABT-CS032 SARS-CoV-2 Spike RBD MAb, clone BIB113 MAb Humanized IgG ELISA, WB
CABT-CS034 SARS-CoV-2 Spike RBD MAb, clone BIB115 MAb Humanized IgG ELISA, WB
CABT-CS044 SARS-CoV-2 Spike RBD MAb, clone BIB116 MAb Humanized IgM ELISA, LFIA
CABT-CS062 SARS-CoV-2 S-RBD MAb (unpurified), clone CTN12 MAb Humanized IgM ELISA, LFIA
CABT-CS060 SARS-CoV-2 S-RBD MAb (purified), clone CTN12 MAb Humanized IgM ELISA, LFIA
CABT-CS049 SARS-CoV-2 Spike Chimeric MAb, clone E113 MAb Chimeric IgG ELISA, IHC-P, FCM, ICC/IF, IP
CABT-CS050 SARS-CoV-2 Spike Chimeric MAb, clone E114 MAb Chimeric IgG ELISA, IHC-P, FCM, ICC/IF, IP
CABT-CS035 SARS-CoV-2 Spike RBD MAb, clone 211184 MAb Mouse IgG ELISA, WB
CABT-CS064 SARS-CoV-2 Spike Neutralizing MAb, clone NN54 MAb Mouse IgG ELISA, Neut
CABT-CS065 SARS-CoV-2 Spike Neutralizing MAb, clone NN68 MAb Mouse IgG ELISA, Neut
CABT-RM321 SARS-CoV-2 spike glycoprotein MAb, clone 118 MAb Rabbit IgG ELISA, IHC-P, FCM, ICC/IF, IP
CABT-CS079 SARS-CoV-2 Spike RBD Neutralizing MAb, clone 112 MAb Rabbit IgG ELISA, WB, Neut
CABT-CS067 SARS-CoV-2 N+S-RBD MAb, clone COTHN12 MAb Humanized IgG,IgM ELISA, LFIA
CABT-CS048 SARS-CoV-2 S2 PAb PAb Rabbit IgG ELISA, WB, IHC-P, FCM, ICC/IF, IP
CABT-CS054 SARS-CoV-2 S2 MAb, clone HM3128 MAb Humanized IgG ELISA, WB
CABT-CS080 SARS-CoV-2 S2 MAb, clone 2B0 MAb Mouse IgG ELISA, WB, IHC-P, ICC/IF, IP, FACS
 N CABT-CS024 SARS-CoV-2 NP PAb PAb Rabbit IgG ELISA, WB
CABT-CS051 SARS-CoV-2 Nucleoprotein MAb, clone TMOPO MAb Humanized IgG ELISA
CABT-CS037 SARS-CoV-2 Nucleoprotein MAb, clone CO10 MAb Humanized IgG ELISA, LFIA
CABT-CS055 SARS-CoV-2 Nucleoprotein MAb (unpurified), clone CON12 MAb Humanized IgM ELISA, LFIA
CABT-CS061 SARS-CoV-2 Nucleoprotein MAb (purified), clone CON12 MAb Humanized IgM ELISA, LFIA
CABT-CS026 SARS-CoV-2 Nucleoprotein MAb, clone 7G21 MAb Mouse IgG ELISA, WB, IHC
CABT-CS027 SARS-CoV-2 Nucleoprotein MAb, clone 4B21 MAb Mouse IgG ELISA
CABT-CS075 SARS-CoV-2 Nucleoprotein MAb, clone 0659 MAb Mouse IgG ELISA, WB, LFIA
CABT-CS076 SARS-CoV-2 Nucleoprotein MAb, clone 0658 MAb Mouse IgG ELISA, WB, LFIA
CABT-RM320 SARS-CoV-2 Nucleoprotein MAb, clone 120 MAb Rabbit IgG ELISA, LFIA
Non-Structural CABT-CS068 SARS-CoV-2 ORF8 PAb PAb Rabbit IgG ELISA
CABT-CS069 SARS-CoV-2 ORF3a PAb PAb Rabbit IgG ELISA
CABT-CS070 SARS-CoV-2 ORF7a PAb PAb Rabbit IgG ELISA
CABT-CS071 SARS-CoV-2 ORF6 PAb PAb Rabbit IgG ELISA
CABT-CS072 SARS-CoV-2 ORF10 PAb PAb Rabbit IgG ELISA
CABT-CS073 SARS-CoV-2 pp1ab PAb PAb Rabbit IgG ELISA

SARS coronavirus, also known as SARS-CoV, emerged in the human population in Guangdong province of southeastern, China in 2002, Within months, the outbreak had spread to 29 countries and regions causing over 8000 human cases and almost 800 deaths in the 2002-2003 outbreak. Phylogenetic analysis of coronavirus from scientist indicated a high probability that SARS coronavirus originated in bats and spread to humans either directly or through animals held in Chinese markets. The bats did not show any visible signs of disease but are the likely natural reservoirs of SARS-like coronaviruses.

Coronaviruses are a family of large, enveloped, positive-stranded RNA viruses that cause upper respiratory, gastrointestinal and central nervous system diseases in humans and other animals. The coronavirinae family consists of four genera based on their genetic properties, including genus alphacoronavirus, genus betacoronavirus, genus gammacoronavirus, and genus deltacoronavirus. Host range and tissue tropism show a lot of variation among different CoVs. Human coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63 and HCoV-HKU1 circulate in humans and cause mild respiratory diseases. However, the outbreak of SARS-CoV in 2002, MERS-CoV in 2012 and SARS-CoV-2 in 2019 showed that coronaviruses can cross the species barrier and emerge as highly pathogenic viruses. SARS-CoV, SARS-CoV-2 and MERS-CoV all belong to the betacoronavirus genus and are zoonotic pathogens that can cause severe respiratory diseases in humans. An outbreak of SARS-CoV-2 disease in 2019 showed many similarities with the SARS-CoV outbreak, and the viral agent was identified as another strain of the SARS-related coronavirus, SARS-CoV-2. Although the two are strains of the same virus, SARS-CoV-2 is not a direct descendant of SARS-CoV, and made the jump into humans separately.

The Viral Structure of SARS-CoV Fig. The Viral Structure of SARS-CoV
Source: Nature Reviews \ Microbiology

SARS-CoV is an enveloped virus with round and sometimes pleiomorphic virions of approximately 80 to 120 nm in diameter. It contains positive-strand RNA, with the largest RNA genome (approximately 30 kb). The genome RNA is complexed with the basic nucleocapsid (N) protein to form a helical capsid found within the viral membrane. The structural proteins of SARS-CoV include the surface spike (S) glycoprotein, the membrane (M) protein, the small envelope (E) glycoprotein, and the nucleocapsid (N) protein. The spike (S) glycoprotein of the coronavirus is a class I viral fusion protein located on the outer envelope of the virion that plays a critical role in viral infection by recognizing host cell receptors and mediating fusion of the viral and cellular membranes. The coronavirus S glycoprotein is synthesized as a precursor protein consisting of ~1,300 amino acids that is then cleaved into an amino (N)-terminal S1 subunit (~700 amino acids) and a carboxyl (C)-terminal S2 subunit (~600 amino acids). Three S1/S2 heterodimers assemble to form a trimer spike protruding from the viral envelope.

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