SARS-CoV-2 Antigens and Antibodies

Creative Diagnostics now can provide a variety of antigens and antibodies of SARS-CoV-2, including SARS-CoV-2 mutant proteins, biotinylated proteins, SARS-CoV-2 antibody pairs, neutralizing antibodies and so on. These antigens and antibodies can be used for scientific research, detection of SARS-CoV-2 and specific antibodies. All of our products are produced using a standardized production process to ensure the highest quality.

SARS-CoV-2 Antigens
SARS-CoV-2 Antibodies

SARS-CoV-2 Spike Mutant Protein

Target	Cat.	Product Name	Source	Tag
S1+S2 ECD	DAGC212	Recombinant SARS-CoV-2 S protein (R683A, R685A) active trimer (MALS verified) [His]	HEK293 cells	His
S1+S2 ECD	DAGC213	Recombinant SARS-CoV-2 S protein (R683A, R685A) [His]	HEK293 cells	His
S1	DAGC210	Recombinant SARS-CoV-2 Spike S1(D614G) Protein [His]	HEK293 cells	His
RBD	DAGC238	Recombinant SARS-CoV-2 Spike RBD Protein (V367F) [mFc]	HEK293 cells	mFc
	DAGC239	Recombinant SARS-CoV-2 Spike RBD Protein (G476S) [His]	HEK293 cells	His
	DAGC186	Recombinant SARS-CoV-2 Spike RBD (V367F) [His]	HEK293 cells	His
	DAGC187	Recombinant SARS-CoV-2 Spike RBD (K458R) [His]	HEK293 cells	His
	DAGC188	Recombinant SARS-CoV-2 Spike RBD (F342L) [His]	HEK293 cells	His
	DAGC189	Recombinant SARS-CoV-2 Spike RBD (V483A) [His]	HEK293 cells	His
	DAGC190	Recombinant SARS-CoV-2 Spike RBD (A435S) [His]	HEK293 cells	His
	DAGC191	Recombinant SARS-CoV-2 Spike RBD (N354D) [His]	HEK293 cells	His
	DAGC217	Recombinant SARS-CoV-2 S protein RBD (N354D, D364Y) [His]	HEK293 cells	His
	DAGC218	Recombinant SARS-CoV-2 S protein RBD (R408I) [His]	HEK293 cells	His
	DAGC219	Recombinant SARS-CoV-2 S protein RBD (W436R) [His]	HEK293 cells	His

Biotinylated SARS-CoV-2 Antigen

Target	Cat.	Product Name	Source	Tag
S1	DAGC215	Biotinylated Recombinant SARS-CoV-2 S1 protein [His,Avi]	HEK293 Cells	His, Avi
S1	DAGC233	Biotinylated Recombinant SARS-CoV-2 S1 Protein [His]	HEK293 Cells	His
RBD	DAGC221	Biotinylated Recombinant SARS-CoV-2 S protein RBD [His,Avi]	HEK293 Cells	His, Avi
	DAGC236	Biotinylated Recombinant SARS-CoV-2 Spike RBD Protein [His,Avi]	Insect Cells	His, Avi
	DAGC234	Biotinylated Recombinant SARS-CoV-2 Spike RBD Protein (HEK293 Cells) [His]	HEK293 Cells	His
	DAGC235	Biotinylated Recombinant SARS-CoV-2 Spike RBD Protein (Insect Cells) [His]	Insect Cells	His
NP	DAGC237	Biotinylated Recombinant SARS-CoV-2 Nucleocapsid Protein [His]	Insect Cells	His
NP	DAGC223	Biotinylated Recombinant SARS-CoV-2 Nucleocapsid protein [His,Avi]	E.coli	His, Avi

SARS-CoV-2 S Protein

Target	Cat.	Product Name	Source	Tag
S1+S2 ECD	DAGC109	Recombinant SARS-CoV-2 Spike Protein [His]	HEK293 cells	His
S1+S2 ECD	DAGC158	Recombinant SARS-CoV-2 Spike(S1+S2 ECD) Protein [His]	Insect Cells	His
S1	*DAGC091	Recombinant SARS-CoV-2 Spike Protein 1 [His]	HEK293 Cells	His
	DAGC092	Recombinant SARS-CoV-2 Spike Protein 1 [human Fc]	HEK293 cells	hFc
	DAGC093	Recombinant SARS-CoV-2 Spike Protein 1 [mouse Fc]	HEK293 cells	mFc
	DAGC138	Recombinant SARS-CoV-2 Spike Protein 1	HEK293 cells
	DAGC157	Recombinant SARS-CoV-2 Spike 1 Protein (truncated) [His]	E.coli	His
	DAGC194	Recombinant SARS-CoV-2 Spike S1 [His]	Insect Cells	His
	DAGC195	Recombinant SARS-CoV-2 Spike S1 NTD [His]	Insect Cells	His
RBD	DAGC209	Recombinant SARS-CoV-2 Spike RBD Protein (a.a. 319-541) [His]	E.coli	His
	DAGC089	Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [Fc]	HEK293 Cells	mFc
	*DAGC149	Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [His]	HEK293 Cells	His
	*DAGC173	Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [hFc]	HEK293 Cells	hFc
	*DAGC174	Recombinant SARS-CoV-2 Spike Protein Receptor Binding Domain [mFc]	HEK293 Cells	mFc
	DAGC183	Recombinant SARS-CoV-2 Spike RBD + SD1 + SD2 [His]	HEK293 Cells	His
	DAGC184	Recombinant SARS-CoV-2 Spike RBD + SD1 [His]	HEK293 Cells	His
	DAGC193	Recombinant SARS-CoV-2 Spike RBD [His]	Insect Cells	His
	DAGC249	Recombinant SARS-CoV-2 Spike RBD (CHO cells) [His]	CHO cells	His
S2	DAGC153	Recombinant SARS-CoV-2 S2 Protein (S2 ECD) [His]	Insect Cells	His

* Highly recommended for the SARS-CoV-2 serology immunoassay development

SARS-CoV-2 NP

Cat.	Product Name	Source	Tag
DAGC094	Recombinant SARS-CoV-2 Nucleocapsid Protein (E.coli) [His]	E.coli	His
DAGC140	Recombinant SARS-CoV-2 Nucleocapsid protein N3 fragment (C-ter domain) [His]	E.coli	His
DAGC141	Recombinant SARS-CoV-2 Nucleocapsid protein N5 fragment (N-ter partiallytruncated) [His]	E.coli	His
*DAGC155	Recombinant SARS-CoV-2 Nucleocapsid Protein (truncated, N3) [His]	E.coli	His
*DAGC156	Recombinant SARS-CoV-2 Nucleocapsid Protein (truncated) [His]	E.coli	His
DAGC161	Recombinant SARS-CoV-2 Nucleocapsid Protein (a.a.1-419) [His]	Insect Cells	His
DAGC192	Recombinant SARS-CoV-2 Nucleocapsid Protein [FLAG]	HEK293 cells	FLAG
DAGC196	Recombinant SARS-CoV-2 Nucleocapsid Protein (HEK293 cells) [His]	HEK293 cells	His

* Highly recommended for the SARS-CoV-2 antibody lateral flow immunoassay development.

SARS-CoV-2 E/M Protein

Cat.	Product Name	Source	Tag
DAGC165	Recombinant SARS-CoV-2 Envelope Protein [His]	E.coli	His
DAGC197	Recombinant SARS-CoV-2 S + M + E Protein [His]	E.coli	His

SARS-CoV-2 Non-Structural Protein

Cat.	Product Name	Source	Tag
DAGC154	Recombinant SARS-CoV-2 papain-like protease [His]	E.coli	His
DAGC166	Recombinant SARS-CoV-2 3C-like Proteinase [His]	E.coli	His
DAGC167	Recombinant SARS-CoV-2 NSP1 [His]	E.coli	His
DAGC171	Recombinant SARS-CoV-2 NSP2 [His]	E.coli	His
DAGC200	Recombinant SARS-CoV-2 NSP3 [His]	E.coli	His
DAGC168	Recombinant SARS-CoV-2 NSP7 [His]	E.coli	His
DAGC169	Recombinant SARS-CoV-2 NSP8 [His]	E.coli	His
DAGC203	Recombinant SARS-CoV-2 NSP9 [His]	E.coli	His
DAGC170	Recombinant SARS-CoV-2 NSP10 [His]	E.coli	His
DAGC202	Recombinant SARS-CoV-2 NSP12 [GST]	E.coli	GST
DAGC205	Recombinant SARS-CoV-2 NSP13 [His]	E.coli	His
DAGC204	Recombinant SARS-CoV-2 NSP15 [His]	E.coli	His
DAGC199	Recombinant SARS-CoV-2 NSP16 [GST]	E.coli	GST
DAGC201	Recombinant SARS-CoV-2 NSP16 [His]	E.coli	His
DAGC172	Recombinant SARS-CoV-2 Guanine-N7_meth [His]	E.coli	His
DAGC224	Recombinant SARS-CoV-2 NSP7 + NSP8 Protein [His]	E.coli	His
DAGC225	Recombinant SARS-CoV-2 NSP16 + NSP10 Heterodimer Protein [His,Strep]	E.coli	His, Strep
DAGC207	Recombinant SARS-CoV-2 ORF3a Protein (a.a. 126-275) [His]	E.coli	His
DAGC206	Recombinant SARS-CoV-2 ORF8 Protein (a.a. 16-121) [His]	E.coli	His

SARS-CoV-2 Receptor Protein

Cat.	Product Name	Source	Tag
DAGC152	Recombinant Human ACE2 Protein [hFc]	HEK293 cells	hFc
DAGC240	Recombinant Human ACE2 Protein [mFc]	HEK293 cells	mFc
DAGC226	Recombinant Human ACE2 Protein [His]	HEK293 cells	His
DAGC245	Recombinant Human ACE2 Protein (HPLC-verified) [His]	Insect Cells	His
DAGC231	Recombinant Mouse ACE2 Protein [His]	HEK293 cells	His
DAGC242	Recombinant Mouse ACE2 Protein [His,hFc]	HEK293 cells	His, hFc
DAGC230	Recombinant Rat ACE2 Protein [His]	HEK293 cells	His
DAGC243	Recombinant Rhesus ACE2 Protein [His]	HEK293 cells	His
DAGC244	Recombinant Rhesus ACE2 Protein [hFc]	HEK293 cells	hFc
DAGC229	Recombinant Cynomolgus ACE2 Protein [His]	HEK293 cells	His
DAGC232	Recombinant Paguma larvata ACE2 Protein [His]	HEK293 cells	His
DAGC227	Biotinylated Recombinant Human ACE2 Protein [Fc,Avi]	HEK293 cells	Fc, Avi
DAGC228	Biotinylated Recombinant Human ACE2 Protein (HEK293 cells) [His,Avi]	HEK293 cells	His, Avi
DAGC241	Biotinylated Recombinant Human ACE2 Protein [His]	HEK293 cells	His
DAGC246	Biotinylated Recombinant Human ACE2 Protein (Insect Cells) [His,Avi]	Insect Cells	His, Avi

SARS-CoV-2 Matched Antibody Pair

Target	Cat.	Product Name	Capture - Detection	Host	Isotype
S	CABT-CS031	SARS-CoV-2 S1 Monoclonal antibody, clone BIB112	CABT-CS031 - CABT-CS033	Humanized	IgG
	CABT-CS033	SARS-CoV-2 S1 Monoclonal antibody, clone BIB114	CABT-CS031 - CABT-CS033	Humanized	IgG
	CABT-CS049	SARS-CoV-2 Spike Chimeric Monoclonal antibody, clone E113	CABT-CS049 - CABT-CS050	Chimeric	IgG
	CABT-CS050	SARS-CoV-2 Spike Chimeric Monoclonal antibody, clone E114	CABT-CS049 - CABT-CS050	Chimeric	IgG
	CABT-CS141	SARS-CoV-2 Trimeric S1 Monoclonal antibody, clone C4587N	CABT-CS141 - CABT-CS142*	Mouse	IgG1
	CABT-CS142	SARS-CoV-2 Trimeric S1 Monoclonal antibody, clone C4589N	CABT-CS141 - CABT-CS142*	Mouse	IgG2b
N	CABT-CS037	SARS-CoV-2 Nucleoprotein Monoclonal antibody, clone CO10	CABT-CS037 - CABT-RM320	Humanized	IgG
	CABT-RM320	SARS-CoV-2 Nucleoprotein monoclonal antibody, clone 120	CABT-CS037 - CABT-RM320	Rabbit	IgG
	CABT-CS075	SARS-CoV-2 Nucleoprotein Monoclonal antibody, clone 0659	CABT-CS075 - CABT-CS076	Mouse	IgG
	CABT-CS076	SARS-CoV-2 Nucleoprotein Monoclonal antibody, clone 0658	CABT-CS075 - CABT-CS076	Mouse	IgG
	CABT-MMB1	Mouse Anti-SARS-CoV-2 NP monoclonal antibody, clone NB1	CABT-MMB1 - CABT-RMJ1*	Mouse	IgG
	CABT-RMJ1	Rabbit anti-SARS-CoV-2 NP monoclonal antibody, clone NJ1	CABT-MMB1 - CABT-RMJ1*	Rabbit	IgG

*Recommended antibody pair for further development of an LFA for SARS-CoV-2 Antigen.

SARS-CoV-2 Neutralizing Antibody

Cat.	Product Name	Host	Isotype
CABT-CS064	SARS-CoV-2 Spike Neutralizing Monoclonal antibody, clone NN54	Mouse	IgG
CABT-CS065	SARS-CoV-2 Spike Neutralizing Monoclonal antibody, clone NN68	Mouse	IgG
CABT-CS079	SARS-CoV-2 Spike RBD Neutralizing Monoclonal antibody, clone 112	Rabbit	IgG
CABT-CS033	SARS-CoV-2 S1 Monoclonal antibody, clone BIB114	Humanized	IgG
CABT-CS056	SARS-CoV-2 S1 Polyclonal antibody	Rabbit	IgG
CABT-CS057	SARS-CoV-2 S1 Polyclonal antibody	Monkey	IgG

SARS-CoV-2 Humanized Antibody- Reliable Alternative to Serum Based Controls

Target	Cat.	Product Name	Host	Isotype
S	CABT-CS033	SARS-CoV-2 S1 Monoclonal antibody, clone BIB114	Humanized	IgG
	CABT-CS044	SARS-CoV-2 Spike RBD Monoclonal antibody (purified), clone BIB116	Humanized	IgM
	CABT-CS062	SARS-CoV-2 S-RBD Monoclonal antibody (unpurified), clone CTN12	Humanized	IgM
	CABT-CS088	Human Anti-SARS-CoV-2 RBD Monoclonal antibody, clone 31Z51	Humanized	IgA
N	CABT-CS037	SARS-CoV-2 Nucleoprotein Monoclonal antibody, clone CO10	Humanized	IgG
	CABT-CS061	SARS-CoV-2 Nucleoprotein Monoclonal antibody (purified), clone CON12	Humanized	IgM
	CABT-CS055	SARS-CoV-2 Nucleoprotein Monoclonal antibody (unpurified), clone CON12	Humanized	IgM
S+N	CABT-CS067	SARS-CoV-2 N+S-RBD Monoclonal antibody (cocktail), clone COTHN12	Humanized	IgG, IgM

SARS-CoV-2 Antibody List

Target	Cat.	Product Name	Type	Host	Isotype	Application
S	CABT-CS066	SARS-CoV-2 Spike PAb	PAb	Rabbit	IgG	WB, ELISA, IHC-P, FCM, ICC/IF, IP
	CABT-CS056	SARS-CoV-2 S1 Neutralizing PAb	PAb	Rabbit	IgG	ELISA, Neut
	CABT-CS057	SARS-CoV-2 S1 Neutralizing PAb	PAb	Monkey	IgG	ELISA, Neut
	CABT-CS031	SARS-CoV-2 S1 MAb, clone BIB112	MAb	Humanized	IgG	ELISA
	CABT-CS033	SARS-CoV-2 S1 MAb, clone BIB114	MAb	Humanized	IgG	ELISA
	CABT-CS052	SARS-CoV-2 S1 MAb, clone CT13	MAb	Humanized	IgG	ELISA
	CABT-CS053	SARS-CoV-2 S1 MAb, clone CT14	MAb	Humanized	IgG	ELISA
	CABT-CS032	SARS-CoV-2 Spike RBD MAb, clone BIB113	MAb	Humanized	IgG	ELISA, WB
	CABT-CS034	SARS-CoV-2 Spike RBD MAb, clone BIB115	MAb	Humanized	IgG	ELISA, WB
	CABT-CS044	SARS-CoV-2 Spike RBD MAb, clone BIB116	MAb	Humanized	IgM	ELISA, LFIA
	CABT-CS062	SARS-CoV-2 S-RBD MAb (unpurified), clone CTN12	MAb	Humanized	IgM	ELISA, LFIA
	CABT-CS060	SARS-CoV-2 S-RBD MAb (purified), clone CTN12	MAb	Humanized	IgM	ELISA, LFIA
	CABT-CS049	SARS-CoV-2 Spike Chimeric MAb, clone E113	MAb	Chimeric	IgG	ELISA, IHC-P, FCM, ICC/IF, IP
	CABT-CS050	SARS-CoV-2 Spike Chimeric MAb, clone E114	MAb	Chimeric	IgG	ELISA, IHC-P, FCM, ICC/IF, IP
	CABT-CS035	SARS-CoV-2 Spike RBD MAb, clone 211184	MAb	Mouse	IgG	ELISA, WB
	CABT-CS064	SARS-CoV-2 Spike Neutralizing MAb, clone NN54	MAb	Mouse	IgG	ELISA, Neut
	CABT-CS065	SARS-CoV-2 Spike Neutralizing MAb, clone NN68	MAb	Mouse	IgG	ELISA, Neut
	CABT-RM321	SARS-CoV-2 spike glycoprotein MAb, clone 118	MAb	Rabbit	IgG	ELISA, IHC-P, FCM, ICC/IF, IP
	CABT-CS079	SARS-CoV-2 Spike RBD Neutralizing MAb, clone 112	MAb	Rabbit	IgG	ELISA, WB, Neut
	CABT-CS067	SARS-CoV-2 N+S-RBD MAb, clone COTHN12	MAb	Humanized	IgG,IgM	ELISA, LFIA
	CABT-CS048	SARS-CoV-2 S2 PAb	PAb	Rabbit	IgG	ELISA, WB, IHC-P, FCM, ICC/IF, IP
	CABT-CS054	SARS-CoV-2 S2 MAb, clone HM3128	MAb	Humanized	IgG	ELISA, WB
	CABT-CS080	SARS-CoV-2 S2 MAb, clone 2B0	MAb	Mouse	IgG	ELISA, WB, IHC-P, ICC/IF, IP, FACS
N	CABT-CS024	SARS-CoV-2 NP PAb	PAb	Rabbit	IgG	ELISA, WB
	CABT-CS051	SARS-CoV-2 Nucleoprotein MAb, clone TMOPO	MAb	Humanized	IgG	ELISA
	CABT-CS037	SARS-CoV-2 Nucleoprotein MAb, clone CO10	MAb	Humanized	IgG	ELISA, LFIA
	CABT-CS055	SARS-CoV-2 Nucleoprotein MAb (unpurified), clone CON12	MAb	Humanized	IgM	ELISA, LFIA
	CABT-CS061	SARS-CoV-2 Nucleoprotein MAb (purified), clone CON12	MAb	Humanized	IgM	ELISA, LFIA
	CABT-CS026	SARS-CoV-2 Nucleoprotein MAb, clone 7G21	MAb	Mouse	IgG	ELISA, WB, IHC
	CABT-CS027	SARS-CoV-2 Nucleoprotein MAb, clone 4B21	MAb	Mouse	IgG	ELISA
	CABT-CS075	SARS-CoV-2 Nucleoprotein MAb, clone 0659	MAb	Mouse	IgG	ELISA, WB, LFIA
	CABT-CS076	SARS-CoV-2 Nucleoprotein MAb, clone 0658	MAb	Mouse	IgG	ELISA, WB, LFIA
	CABT-RM320	SARS-CoV-2 Nucleoprotein MAb, clone 120	MAb	Rabbit	IgG	ELISA, LFIA
Non-Structural	CABT-CS068	SARS-CoV-2 ORF8 PAb	PAb	Rabbit	IgG	ELISA
	CABT-CS069	SARS-CoV-2 ORF3a PAb	PAb	Rabbit	IgG	ELISA
	CABT-CS070	SARS-CoV-2 ORF7a PAb	PAb	Rabbit	IgG	ELISA
	CABT-CS071	SARS-CoV-2 ORF6 PAb	PAb	Rabbit	IgG	ELISA
	CABT-CS072	SARS-CoV-2 ORF10 PAb	PAb	Rabbit	IgG	ELISA
	CABT-CS073	SARS-CoV-2 pp1ab PAb	PAb	Rabbit	IgG	ELISA

SARS coronavirus, also known as SARS-CoV, emerged in the human population in Guangdong province of southeastern, China in 2002, Within months, the outbreak had spread to 29 countries and regions causing over 8000 human cases and almost 800 deaths in the 2002-2003 outbreak. Phylogenetic analysis of coronavirus from scientist indicated a high probability that SARS coronavirus originated in bats and spread to humans either directly or through animals held in Chinese markets. The bats did not show any visible signs of disease but are the likely natural reservoirs of SARS-like coronaviruses.

Coronaviruses are a family of large, enveloped, positive-stranded RNA viruses that cause upper respiratory, gastrointestinal and central nervous system diseases in humans and other animals. The coronavirinae family consists of four genera based on their genetic properties, including genus alphacoronavirus, genus betacoronavirus, genus gammacoronavirus, and genus deltacoronavirus. Host range and tissue tropism show a lot of variation among different CoVs. Human coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63 and HCoV-HKU1 circulate in humans and cause mild respiratory diseases. However, the outbreak of SARS-CoV in 2002, MERS-CoV in 2012 and SARS-CoV-2 in 2019 showed that coronaviruses can cross the species barrier and emerge as highly pathogenic viruses. SARS-CoV, SARS-CoV-2 and MERS-CoV all belong to the betacoronavirus genus and are zoonotic pathogens that can cause severe respiratory diseases in humans. An outbreak of SARS-CoV-2 disease in 2019 showed many similarities with the SARS-CoV outbreak, and the viral agent was identified as another strain of the SARS-related coronavirus, SARS-CoV-2. Although the two are strains of the same virus, SARS-CoV-2 is not a direct descendant of SARS-CoV, and made the jump into humans separately.

The Viral Structure of SARS-CoV Fig. The Viral Structure of SARS-CoV
Source: Nature Reviews \ Microbiology

SARS-CoV is an enveloped virus with round and sometimes pleiomorphic virions of approximately 80 to 120 nm in diameter. It contains positive-strand RNA, with the largest RNA genome (approximately 30 kb). The genome RNA is complexed with the basic nucleocapsid (N) protein to form a helical capsid found within the viral membrane. The structural proteins of SARS-CoV include the surface spike (S) glycoprotein, the membrane (M) protein, the small envelope (E) glycoprotein, and the nucleocapsid (N) protein. The spike (S) glycoprotein of the coronavirus is a class I viral fusion protein located on the outer envelope of the virion that plays a critical role in viral infection by recognizing host cell receptors and mediating fusion of the viral and cellular membranes. The coronavirus S glycoprotein is synthesized as a precursor protein consisting of ~1,300 amino acids that is then cleaved into an amino (N)-terminal S1 subunit (~700 amino acids) and a carboxyl (C)-terminal S2 subunit (~600 amino acids). Three S1/S2 heterodimers assemble to form a trimer spike protruding from the viral envelope.