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Recombinant SARS-CoV-2 Omicron Variant (B.1.1.529) Protein

The Omicron variant, with a large number of spike gene mutations was designated a variant of concern (VOC). There is still considerable uncertainty related to the transmissibility, vaccine effectiveness, severity of infection and other properties of the Omicron variant. Preliminary evidence suggests there may be an increased risk of reinfection with Omicron. Creative Diagnostics has been tracking the most up-to-date genomic data of the virus and developing a series of recombinant SARS-CoV-2 variant proteins to support the study of variant.

Mutations in the Spike Protein of Omicron

  • 30 changes (A67V, T95I, G142D, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F)
  • Three deletions (Δ69-70, Δ143-145, Δ211)
  • One insertion (ins214EPE)

Stanford University Coronavirus Database

Figure Source: Stanford University Coronavirus Database

Product List

Recombinant SARS-CoV-2 Omicron Variant (B.1.1.529) Protein
Cat. No Protein Name Expression System Tag Mutation Site
DAG-WT549 NTD HEK293 cells His A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE
DAG-WT547 RBD HEK293 cells His G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H
DAG-WT555 RBD HEK293 cells His, Avi G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H
DAG-WT550 RBD HEK293 cells His, Avi, Biotinylated G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H
DAG-WT557 S1 HEK293 cells His A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H
DAG-WT548 Spike Trimer HEK293 cells His A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
DAG-WT551 Spike Trimer HEK293 cells His, Avi, Biotinylated A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
DAG-WT553 S-ECD Insect cells His A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
DAG-WT554 S-ECD HEK293 cells His, Avi A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
DAG-WT552 N E. coli His P13L, Δ31-33, R203K, G204R
DAG-WT556 N HEK293 cells His P13L, Δ31-33, R203K, G204R

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