Recombinant Helicobacter Pylori Antigens — For Vaccine Research and Development

Helicobacter pylori (H. pylori), a powerful carcinogenic pathogen, is responsible for the induction of 75% of gastric cancers worldwide. In general, the current treatment for patients who are infected with H. pylori consists of daily administration of three antibiotics, proton pump inhibitor, amoxicillin, clarithromycin. But the resistance of H. pylori to antibiotics is increasing day by day. Effective vaccine is a promising alternative to reach the global eradication of H. pylori. However, most vaccines currently under development are at a very early stage.
Creative Diagnostics offers a series of recombinant H. pylori antigens, including catalase, urease, CagA, VacA and other recombinant proteins. These potential H. pylori candidate antigens are designed to support your vaccine development.

Virulence factors

• Flagella located at one pole of the bacterial cell. Each flagellum is principally composed of a filament made of the flagellin A and B (FlaA/B), surrounded by a membranous sheath containing many different proteins. H. pylori flagella may influence their colonization in bacteria, inflammation, and immune evasion.
• Urease, an important virulence factor involved in a series of processes that allow bacteria to colonize and induce a strong inflammatory response in the gastric epithelium. Urease consisting of a dodecameric organization of two subunits (UreA, 26.5 kDa; UreB, 61.7 kDa).
• The outer membrane protein plays a pivotal role in the attachment and colonization of gastric cells. Sialic acid-binding adhesin (SabA), blood-group-antigen-binding adhesin (BabA), adherence-associated lipoprotein A and B (AlpA/B), outer inflammatory protein A (OipA), and Helicobacter outer membrane protein Q (HopQ) were involved in adhesion.
• The cytotoxin-associated genes (cag) pathogenicity island and the vacuolating cytotoxin (VacA) are two major cytotoxins associated with more severe disease. CagA affects the adhesion, spreading, and migration of the cell. VacA can help H. pylori colonization. Moreover, CagA and VacA can also affect the host cell in several aspects.