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M. Tuberculosis Antigens

Creative Diagnostics offers a large range of M. Tuberculosis antigens which have been validated to work in various types of immunoassays. Several of these products are currently being used in commercial diagnostic assays.

Tuberculosis (TB) is a contagious and often severe airborne disease caused by infection with Mycobacterium tuberculosis (Mtb) bacteria. Once rare in developed countries, tuberculosis infections began increasing in 1985, partly because of the emergence of HIV, the virus that causes AIDS. HIV weakens a person's immune system so it can't fight the TB germs. And in 1993, the World Health Organization (WHO) declared that TB was a global emergency; the first time that a disease had been labelled as such. Fortunately, with proper treatment almost all cases of tuberculosis are curable. Cases of TB have decreased in the US since 1993, but the disease remains a concern.

Tuberculosis usually affects the lungs, but can also affect other parts of the body. When TB occurs outside of the lungs, the symptoms can vary accordingly. Without treatment, TB can spread to other parts of the body through the bloodstream.

Mycobacterium tuberculosis is a fairly large nonmotile rod-shaped bacterium distantly related to the Actinomycetes. M. tuberculosis has an unusual, waxy coating on the cell surface (primarily mycolic acid), which makes the cells impervious to Gram staining. Humans are the only known reservoirs of M. tuberculosis. One-third of the world's population is thought to be infected with TB disease, and the BCG vaccine has had success in preventing tuberculosis.

Diagnosing active tuberculosis based only on signs and symptoms is difficult. A chest X-ray and multiple sputum cultures for acid-fast bacilli are typically part of the initial evaluation, but these methods are of low accuracy. Tuberculin skin tests are the most common diagnostic method in the past decade, but false-positive results may be presented. Recently, interferon-γ release assays (IGRAs) have been developed to measure IFN-γ responses to infection in blood samples. Test results of IGRAs can be available in 24 hours and BCG vaccination does not cause a false-positive result.

M. Tuberculosis Antigens

Cat_No Product Name Expression system Application
DAGA-169 Recombinant M. Tuberculosis 15.3 kDa E. coli ELISA, LFIA, WB
DAG-T2449 Recombinant M. Tuberculosis 16 kDa E. coli EIA, ELISA
DAG-T2447 Recombinant M. Tuberculosis 38 kDa E. coli EIA, ELISA
DAGA-191 Recombinant M. Tuberculosis 48 kDa E. coli ELISA
DAGA-190 Recombinant M. Tuberculosis 63 kDa E. coli ELISA, WB
DAGA-181 Recombinant M. Tuberculosis 85-A E. coli WB, ELISA
DAGA-192 Recombinant M. Tuberculosis 85-A Hi-5 cells SDS-PAGE
DAGA-189 Recombinant M. Tuberculosis 85-A Baculovirus SDS-PAGE
DAGA-185 Recombinant M. Tuberculosis 85-B E. coli WB, ELISA
DAGA-175 Recombinant M. Tuberculosis 85-C E. coli WB, ELISA
DAGA-170 Recombinant M. Tuberculosis CFP-10 E. coli ELISA
DAGA-193 Recombinant M. Tuberculosis CFP10/ ESAT6 Chimera Protein E. coli EIA, WB
DAGA-187 Recombinant M. Tuberculosis ESAT-6 E. coli WB, ELISA
DAGA-168 Native M. Tuberculosis LAM Antigen Native ELISA
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