Creative Diagnostics offers a large range of M. Tuberculosis antigens which have been validated to work in various types of immunoassays. Several of these products are currently being used in commercial diagnostic assays.
Tuberculosis (TB) is a contagious and often severe airborne disease caused by infection with Mycobacterium tuberculosis (Mtb) bacteria. Once rare in developed countries, tuberculosis infections began increasing in 1985, partly because of the emergence of HIV, the virus that causes AIDS. HIV weakens a person's immune system so it can't fight the TB germs. And in 1993, the World Health Organization (WHO) declared that TB was a global emergency; the first time that a disease had been labelled as such. Fortunately, with proper treatment almost all cases of tuberculosis are curable. Cases of TB have decreased in the US since 1993, but the disease remains a concern.
Tuberculosis usually affects the lungs, but can also affect other parts of the body. When TB occurs outside of the lungs, the symptoms can vary accordingly. Without treatment, TB can spread to other parts of the body through the bloodstream.
Mycobacterium tuberculosis is a fairly large nonmotile rod-shaped bacterium distantly related to the Actinomycetes. M. tuberculosis has an unusual, waxy coating on the cell surface (primarily mycolic acid), which makes the cells impervious to Gram staining. Humans are the only known reservoirs of M. tuberculosis. One-third of the world's population is thought to be infected with TB disease, and the BCG vaccine has had success in preventing tuberculosis.
Diagnosing active tuberculosis based only on signs and symptoms is difficult. A chest X-ray and multiple sputum cultures for acid-fast bacilli are typically part of the initial evaluation, but these methods are of low accuracy. Tuberculin skin tests are the most common diagnostic method in the past decade, but false-positive results may be presented. Recently, interferon-γ release assays (IGRAs) have been developed to measure IFN-γ responses to infection in blood samples. Test results of IGRAs can be available in 24 hours and BCG vaccination does not cause a false-positive result.
|Cat_No||Product Name||Expression system||Application|
|DAGA-169||Recombinant M. Tuberculosis 15.3 kDa||E. coli||ELISA, LFIA, WB|
|DAG-T2449||Recombinant M. Tuberculosis 16 kDa||E. coli||EIA, ELISA|
|DAG-T2447||Recombinant M. Tuberculosis 38 kDa||E. coli||EIA, ELISA|
|DAGA-191||Recombinant M. Tuberculosis 48 kDa||E. coli||ELISA|
|DAGA-190||Recombinant M. Tuberculosis 63 kDa||E. coli||ELISA, WB|
|DAGA-181||Recombinant M. Tuberculosis 85-A||E. coli||WB, ELISA|
|DAGA-192||Recombinant M. Tuberculosis 85-A||Hi-5 cells||SDS-PAGE|
|DAGA-189||Recombinant M. Tuberculosis 85-A||Baculovirus||SDS-PAGE|
|DAGA-185||Recombinant M. Tuberculosis 85-B||E. coli||WB, ELISA|
|DAGA-175||Recombinant M. Tuberculosis 85-C||E. coli||WB, ELISA|
|DAGA-170||Recombinant M. Tuberculosis CFP-10||E. coli||ELISA|
|DAGA-193||Recombinant M. Tuberculosis CFP10/ ESAT6 Chimera Protein||E. coli||EIA, WB|
|DAGA-187||Recombinant M. Tuberculosis ESAT-6||E. coli||WB, ELISA|
|DAGA-168||Native M. Tuberculosis LAM Antigen||Native||ELISA|