New Products

ELISA Kits for Antimicrobial Drugs Detection

Creative Diagnostics offers several new ELISA Kits for quantitative and qualitative analysis of antimicrobial drugs in different kinds of samples. Each of our kits goes through fit-for-purpose validation and stability testing to ensure high accuracy, sensitivity and specificity.

Our Products:

Drug Class Antimicrobial Drug Name IC50
(ppb)
Sample
Cephalosporins Cefquinome 2 milk
Cefalexin 0.5 milk, tissue, honey and urine
Quinolones 3-methyl-quinosaline-2-carboxylicacid 5 chicken, duck and other sample types
Ciprofloxacin 0.5 tissues, honey, milk, milk powder, egg
Sulfonamide Sulfadiazine 1 tissue, serum, honey, milk
Sulfanilamides 0.5 chickens, pigs, fish, shrimp, honey, etc.
Others Vancomycin 1 human serum or plasma
Pirlimycin 5 milk
Thiamphenicol drug residue 0.15 raw milk, egg, seafood, tissue
Albendazole 10 meat and feed
Natamycin 2 biological agents

What is Antimicrobial Drugs?

Antimicrobial drug is a kind of drug used to treat a microbial infection. Antimicrobial is a general term that refers to a group of drugs that includes antibiotics, antifungals, antiprotozoals, and antivirals. They are derived from bacteria or molds or are synthesized de novo. Technically, “antibiotic” refers only to antimicrobials derived from bacteria or molds but is often used synonymously with “antibacterial drug.”

ELISA Kits for Antimicrobial Drugs Detection

What is the difference between antibiotic and antimicrobial?

The terms antimicrobial and antibiotic encompass a wide variety of pharmaceutical agents that include antibacterial, antifungal, antiviral, and antiparasitic drugs. But what is the difference between antibiotic and antimicrobial substances?

Technically:

  • Antibiotics are used to kill microbes (literally ‘life’)
  • Antimicrobials are used to kill or prevent further growth of microbes
  • Antibacterials are used to kill or prevent further growth bacteria
  • Antivirals are used to treat viral infections
  • Antifungal are used to kill or prevent further growth of fungi
  • Antiparasitic act against parasites

Mechanisms of Antimicrobial Drugs

Most antimicrobial drugs currently in clinical use are antibacterial because the prokaryotic cell provides a greater variety of unique targets for selective toxicity, in comparison to fungi, parasites, and viruses. Antibiotics have many mechanisms of action, including inhibiting cell wall synthesis, increasing cell membrane permeability, and interfering with protein synthesis, nucleic acid metabolism, and other metabolic processes (eg, folic acid synthesis). The figure and table below summarized the way in which a drug affects microbes at the cellular level. These drugs have very serious side effects and will cause bacilus resistance if they exist in human body for a long period. They also have potential carcinogenecity.

ELISA Kits for Antimicrobial Drugs Detection

 

Table 1. Common Antibacterial Drugs by Mode of Action
Mode of Action Target Drug Class
Inhibit cell wall biosynthesis Penicillin-binding proteins β-lactams: penicillins, cephalosporins, monobactams, carbapenems
Peptidoglycan subunits Glycopeptides
Peptidoglycan subunit transport Bacitracin
Inhibit biosynthesis of proteins 30S ribosomal subunit Aminoglycosides, tetracyclines
50S ribosomal subunit Macrolides, lincosamides, chloramphenicol, oxazolidinones
Disrupt membranes Lipopolysaccharide, inner and outer membranes Polymyxin B, colistin, daptomycin
Inhibit nucleic acid synthesis RNA Rifamycin
DNA Fluoroquinolones
Antimetabolites Folic acid synthesis enzyme Sulfonamides, trimethoprim
Mycolic acid synthesis enzyme Isonicotinic acid hydrazide
Mycobacterial adenosine triphosphate (ATP) synthase inhibitor Mycobacterial ATP synthase Diarylquinoline

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