Creative Diagnostics offers monoclonal and polyclonal antibodies against different categories of cytotoxic drug: Tubulin Inhibitor; DNA Damaging; RNA Polymerase II and III Inhibitor; DNA Topoisomerase I Inhibitor and DNA Inhibitor.
Currently, the launched products are for research purposes only, not for use in diagnostics. More payload antibodies are under development.
|Cat. No||Product Name||Host||Payload Category|
|CABT-L3104||Anti-DM1/4 Pab||Rabbit||Tubulin Inhibitor|
|CABT-B8996||Anti-DM1 Pab||Mouse||Tubulin Inhibitor|
|CABT-L3105||Anti-DM1/4 Mab||Mouse||Tubulin Inhibitor|
|CABT-L3103||Anti-MMAE / F Mab||Mouse||Tubulin Inhibitor|
|CABT-B8992||Anti-MMAE Mab||Mouse||Tubulin Inhibitor|
|CABT-B8993||Anti-MMAE Mab [Biotin]||Mouse||Tubulin Inhibitor|
|CABT-B8997||Anti-MMAE Pab||Mouse||Tubulin Inhibitor|
|CABT-B8994||Anti-MMAF Mab||Mouse||Tubulin Inhibitor|
|CABT-B8995||Anti-MMAF Mab [Biotin]||Mouse||Tubulin Inhibitor|
|CABT-L3102||Anti-MMAF Pab||Rabbit||Tubulin Inhibitor|
|CABT-B8998||Anti-MMAF Pab||Mouse||Tubulin Inhibitor|
|CABT-L3101||Anti-vc-PAB-MMAE Mab||Mouse||Tubulin Inhibitor|
|CABT-L3100||Anti-vc-PAB-MMAE Pab||Rabbit||Tubulin Inhibitor|
DM1 / DM4 can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
MMAE / MMAF are antitubulin agent that inhibit cell division by blocking the polymerization of tubulin.
|CABT-L3109||Anti-Duocarmycin Mab||Mouse||DNA Damaging|
|CABT-L3108||Anti-Duocarmycin Pab||Rabbit||DNA Damaging|
|CABT-L3107||Anti-Calicheamicin Mab||Mouse||DNA Damaging|
|CABT-L3106||Anti-Calicheamicin Pab||Rabbit||DNA Damaging|
Duocarmycin binds to the minor groove of DNA and alkylate the nucleobase adenine at the N3 position, which eventually leads to cell death.
Calicheamicin targets DNA and cause strand scission.
|CABT-L3117||Anti-PBD SG3199 Mab||Mouse||DNA Inhibitor|
|CABT-L3116||Anti-PBD SG3199 Pab||Rabbit||DNA Inhibitor|
|CABT-L3111||Anti-PNU-159682 Mab||Mouse||DNA Inhibitor|
|CABT-L3110||Anti-PNU-159682 Pab||Rabbit||DNA Inhibitor|
PBD (pyrrolobenzodiazepine) are a class of sequence-selective DNA minor-groove binding crosslinking agents, which are significantly more potent than systemic chemotherapeutic drugs.
PNU-159682 is a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity, and it is a topoisomerase inhibitor.
|CABT-L3113||Anti-Amanitin Mab||Mouse||RNA Polymerase II and III Inhibitor|
|CABT-L3112||Anti-Amanitin Pab||Rabbit||RNA Polymerase II and III Inhibitor|
|Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.|
|CABT-L3115||Anti-SN38 Mab||Mouse||DNA Topoisomerase I Inhibitor|
|CABT-L3114||Anti-SN38 Pab||Rabbit||DNA Topoisomerase I Inhibitor|
|Browse All Cytotoxic Drug Antibodies＞＞|
ADCs (Antibody–drug conjugates) are emerging as powerful cancer treatments that combine antibody-mediated tumor targeting with the potent cytotoxic activity of toxins and permit sensitive discrimination between healthy and diseased tissue. Due to its high potent toxins, the pharmacokinetic properties need to be extensively evaluated. So, the ratio of conjugated and total antibody needs to be measured using immuno-colorimetric assays by an agent that targets the drug portion after certain time period of deployment.
With team of antibody experts working in a state-of-the-art laboratory, Creative Diagnostics is proud to announce that a new set of antibodies specific to Cytotoxic Drugs are now commercially available. Using these newly launched antibodies, we were able to successfully develop highly sensitive MMAE and MMAF ELISA kits.
More in development, coming soon!