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Creative Diagnostics is constantly working in order to bring best-in–market reagents for troponin measurements. Now we are offering new reagents for Troponin-I antibody pair for the development of highly sensitive and specific cTnI sandwich immunoassays.
All of the anti-troponin I monoclonal antibodies have been on the clinical diagnostic market since 1998. Among them, clone TPC110 have dominated about 70% of US clinical diagnostic market since 1998. It is still one of the most popular monoclonal antibodies (N24-40 position) for the imunodiagnostic applications of Myocardial Infarction.
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The cardiac marker Troponin I (cTnI) is useful for the diagnosis of myocardial infarction (MI) and the risk stratification to help guide the choice of therapeutic options. The cardiac-specific troponins, Troponin-I (cTnI) and Troponin-T (cTnT) are considered the biochemical markers of choice in the evaluation of acute coronary syndromes (ACS). Elevated levels of cTnI in patients have a statistically significant increase in mortality or increases in other non-fatal cardiac events such as non-fatal MI, congestive heart failure, and urgent revascularization.
| Antibodies | Kd | Epitope location | |
| DMAB4456MH | 0.46nM | N 24-40 | Inquiry |
| DMAB4452MH | 0.37nM | N 24-40 | Inquiry |
| DCAB-TJ202 | 0.76nM | N 24-40 | Inquiry |
| DCAB-TJ201 | 0.39nM | N 59-79 | Inquiry |
| DCAB-TJ203 | 1.93nM | N 80-95 | Inquiry |
| Capture | Detection (HRP conjugated) | Min. Sensitivity (ng/ml) |
| DCAB-TJ202 | DMAB4456MH/DMAB4452MH | 0.2 |
| DCAB-TJ201 | DMAB4456MH/DMAB4452MH | 0.1 * |
| DCAB-TJ203 | DMAB4456MH/DMAB4452MH | 0.3 |
| DCAB-TJ202 and DCAB-TJ201 (1:1) | DMAB4456MH/DMAB4452MH | 0.1 |
| DCAB-TJ202 and DCAB-TJ201 and DCAB-TJ203 (1:1:1) | DMAB4456MH/DMAB4452MH | 0.1 |
*Rated as one of the best pairing for ELISA of troponin I.
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