An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body. Such reactions are called allergies. The first time a person is exposed to an allergen, they do not usually experience a reaction. It often takes time for the immune system to build up a sensitivity to the substance. In time, the immune system learns to recognize and remember the allergen. As it does so, it starts making antibodies to attack it when exposure occurs. This buildup is called sensitization. Allergy symptoms can affect the human airways, sinuses and nasal passages, skin, and digestive system. Allergic reactions can range from mild to severe. In some severe cases, allergies can trigger a life-threatening reaction known as anaphylaxis.
Immunoglobulin E (IgE)-mediated allergy is the most common hypersensitivity disease affecting more than 30% of the population. Exposure to even minute quantities of allergens can lead to the production of IgE antibodies in atopic individuals. This is termed allergic sensitization, which occurs mainly in early childhood. Allergen-specific IgE then binds to the high (FcεRI) and low-affinity receptors (FcεRII, also called CD23) for IgE on effector cells and antigen-presenting cells. Subsequent and repeated allergen exposure increases allergen-specific IgE levels and, by receptor cross-linking, triggers immediate release of inflammatory mediators from mast cells and basophils whereas IgE-facilitated allergen presentation perpetuates T cell–mediated allergic inflammation. Due to engagement of receptors which are highly selective for IgE, even tiny amounts of allergens can induce massive inflammation. Naturally occurring allergen-specific IgG and IgA antibodies usually recognize different epitopes on allergens compared with IgE and do not efficiently interfere with allergen-induced inflammation. However, IgG and IgA antibodies to these important IgE epitopes can be induced by allergen-specific immunotherapy or by passive immunization. These will lead to competition with IgE for binding with the allergen and prevent allergic responses. Similarly, anti-IgE treatment does the same by preventing IgE from binding to its receptor on mast cells and basophils.
Fig. 1. Pump priming of the allergic response by allergens (Hannah J. Gould & Brian J. Sutton. 2008)
Many different types of allergens can trigger an allergic reaction, a very broad range of substances also can be allergens to sensitive individuals. The types of allergies including food allergies, drug allergies, insect allergies, latex allergies, mold allergies, pet allergies, pollen allergies and other allergies. An allergic reaction can be caused by any form of direct contact with the allergen—consuming food or drink, breathing in pollen, perfume or pet dander, or brushing a body part against an allergy-causing plant. In the U.S, the most common causes of food allergy are these eight foods: Milk, egg, peanut, tree nut, soy, wheat, fish, shellfish. Other common causes of serious allergy are wasp, fire ant and bee stings, penicillin, and latex.
With years of experience in production of purified allergens, Creative Diagnostics now can provide our customers various food allergens, plant allergens, animal allergens and fungal allergens with high-quality and cheaper price. These allergens can be used in animal models of IgE responses, antibody detection and biologic assays. Welcome to contact us for more details.
| • Food allergens | ||||
| Analyte | Cat.No | Product Name | Expression System | |
| Arachis hypogaea | DAG-WT160 | Recombinant Arachis hypogaea Ara h 9.0101 [His] | Insect cells | Inquiry |
| DAG-WT162 | Recombinant Arachis hypogaea Ara h 8.0101 [His] | E. coli | Inquiry | |
| DAG-WT159 | Recombinant Arachis hypogaea Ara h 6.0101 [His] | Insect cells | Inquiry | |
| DAG-WT161 | Recombinant Arachis hypogaea Ara h 3.0101 [His] | E. coli | Inquiry | |
| Charybdis feriatus | DAG-WT213 | Recombinant Charybdis feriata Cha f 1 [His] | E. coli | Inquiry |
| Corylus avellana | DAG-WT167 | Native Corylus avellana Cor a 9 | Hazelnut | Inquiry |
| DAG-WT166 | Recombinant Corylus avellana Cor a 8.0101 [His] | Insect cells | Inquiry | |
| DAG-WT168 | Recombinant Corylus avellana Cor a 14.0101 [His] | Insect cells | Inquiry | |
| DAG-WT158 | Recombinant Cor a 1.0401 [His] | Insect cells | Inquiry | |
| Gadus callarias | DAG-WT294 | Recombinant Gadus callarias Gad c 1 | E. coli | Inquiry |
| Gallus domesticus | DAG-WT222 | Recombinant Chicken Gal d 6 [His] | Mammalian cells | Inquiry |
| DAG-WT220 | Recombinant Chicken Gal d 5 [His] | Mammalian cells | Inquiry | |
| DAG-WT218 | Recombinant Chicken Gal d 4 [His] | Mammalian cells | Inquiry | |
| DAG-WT223 | Recombinant Chicken Gal d 3 [His] | Mammalian cells | Inquiry | |
| DAG-WT219 | Recombinant Chicken Gal d 2 [His] | E. coli | Inquiry | |
| DAG-WT221 | Recombinant Chicken Gal d 1 [His] | Mammalian cells | Inquiry | |
| Glycine max | DAG-WT289 | Recombinant Glycine max Gly m 4 | E. coli | Inquiry |
| DAG-WT290 | Recombinant Glycine max Gly m 5 | E. coli | Inquiry | |
| Malus domestica | DAG-WT165 | Recombinant Malus domestica Mal d 3.0101 [His] | Insect cells | Inquiry |
| DAG-WT163 | Recombinant Malus domestica Mal d 1.0108 [His] | E. coli | Inquiry | |
| DAG-WT264 | Recombinant Malus Domestica Mal d 4 [His] | E. coli | Inquiry | |
| Mangifera indica | DAG-WT295 | Recombinant Mangifera indica Man i 1 | E. coli | Inquiry |
| DAG-WT296 | Recombinant Mangifera indica Man i 3 | E. coli | Inquiry | |
| Penaeus aztecus | DAG-WT164 | Recombinant Penaeus aztecus Pen a 1.0101 [His] | Insect cells | Inquiry |
| Prunus persica | DAG-WT288 | Recombinant Prunus persica Pru p 1 | E. coli | Inquiry |
| Sesamum indicum | DAG-WT291 | Recombinant Sesamum indicum Ses I 1 | E. coli | Inquiry |
| Triticum aestivum | DAG-WT211 | Recombinant allergen Tri a 19 [His] | E. coli | Inquiry |
| DAG-WT169 | Recombinant Triticum aestivum Tri a 14.0101 [His] | Insect cells | Inquiry | |
| DAG-WT266 | Recombinant Triticum Aestivum Tri a 12 [His] | E. coli | Inquiry | |
| • Plant allergens | ||||
| Analyte | Cat.No | Product Name | Expression System | |
| Alnus glutinosa | DAG-WT282 | Recombinant Alnus glutinosa Aln g 1 | E. coli | Inquiry |
| Ambrosia artemisiifolia | DAG-WT280 | Recombinant Ambrosia artemisiifolia Amb a 1 | E. coli | Inquiry |
| DAG-WT281 | Recombinant Ambrosia artemisiifolia Amb a 2 | E. coli | Inquiry | |
| Artemisia vulgaris | DAGA-3100 | Recombinant Mugwort Art v3. [His] | E. coli | Inquiry |
| DAGA-3099 | Recombinant Mugwort Art v1. [His] | Pichia pastoris | Inquiry | |
| Betula verrucosa | DAG-WT174 | Recombinant Betula verrucosa Bet v 6.0101 [His] | E. coli | Inquiry |
| DAG-WT173 | Recombinant Betula verrucosa Bet v 4.0101 [His] | Insect cells | Inquiry | |
| DAGK-008 | Bet v 2.0101 (full length) [His] | E. coli | Inquiry | |
| DAGK-007 | Bet v 1.0101 (full length) [His] | Insect cells | Inquiry | |
| Carpinus betulus | Recombinant Carpinus betulus Car b 1 | E. coli | Inquiry | |
| Chenopodium album | DAG-WT284 | Recombinant Chenopodium album Che a 1 | Mammalian cells | Inquiry |
| DAG-WT285 | Recombinant Chenopodium album Che a 2 | E. coli | Inquiry | |
| DAG-WT286 | Recombinant Chenopodium album Che a 3 | E. coli | Inquiry | |
| Fraxinus excelsior | DAGK-011 | Fra e 1.0101 (full length) [His] | Insect cells | Inquiry |
| Humulus japonicus | DAG-WT287 | Recombinant Humulus japonicus Hum j 1 | E. coli | Inquiry |
| Phleum pratense | DAGA-3095 | Recombinant Timothy Grass Phl p 7 [His] | E. coli | Inquiry |
| DAGK-006 | Phl p 6.0101 (full length) [His] | Insect cells | Inquiry | |
| DAGA-3093 | Recombinant Timothy Grass Phl p 5a [His] | E. coli | Inquiry | |
| DAGA-3094 | Recombinant Timothy Grass Phl p 5b [His] | E. coli | Inquiry | |
| DAGK-004 | Phl p 2.0101 (full length) [His] | Insect cells | Inquiry | |
| DAG-WT171 | Recombinant Phleum pretense Phl p 12.0101 [His] | Insect cells | Inquiry | |
| DAGK-003 | Phl p 1.0102 (full length) [His] | Insect cells | Inquiry | |
| Platanus acerifolia | DAGA-3098 | Recombinant Plane Tree Pla a3. [His] | E. coli | Inquiry |
| DAGA-3097 | Recombinant Plane Tree Pla a1. [His] | Pichia pastoris | Inquiry | |
| DAG-WT265 | Recombinant Platanus acerifolia Pla a 2 [His] | Mammalian cells | Inquiry | |
| • Animal allergens | ||||
| Analyte | Cat.No | Product Name | Expression System | |
| Blattella germanica | DAG-WT277 | Recombinant Blattella germanica Bla g 4 | E. coli | Inquiry |
| DAG-WT278 | Recombinant Blattella germanica Bla g 5 | E. coli | Inquiry | |
| Bos domesticus | DAG-WT216 | Recombinant Bovine Bos d 8 [His] (Mammalian) | Mammalian cells | Inquiry |
| DAG-WT214 | Recombinant Bovine Bos d 4 [His] | Mammalian cells | Inquiry | |
| DAG-WT215 | Recombinant Bovine Bos d 11 [His] | E. coli | Inquiry | |
| DAG-WT292 | Recombinant Bos domesticus Bos d 2 | E. coli | Inquiry | |
| Canis familiaris | DAGA-3086 | Recombinant Dog allergen, can f5. [His] | Pichia pastoris | Inquiry |
| DAGA-3088 | Recombinant Dog allergen, can f1. [His] | E. coli | Inquiry | |
| Dermatophagoides farinae | DAGA-3090 | Recombinant Dust Mite Der f2. [His] | Pichia pastoris | Inquiry |
| Dermatophagoides pteronyssinus | DAGA-3089 | Recombinant Dust Mite Der p10 [His] | E. coli | Inquiry |
| DAG-WT259 | Recombinant Dust Mite Der p 6 [GST] | E. coli | Inquiry | |
| DAG-WT260 | Recombinant Dust Mite Der p 23 [His] | Mammalian cells | Inquiry | |
| DAG-WT261 | Recombinant Dust Mite Der p 2 [His] | E. coli | Inquiry | |
| Equus caballus | DAGA-3087 | Recombinant Equus caballus (Equ c) 1inant [His] | E. coli | Inquiry |
| Felis domesticus | DAGA-3085 | Recombinant Cat allergen fel d1 [His] | Pichia pastoris | Inquiry |
| DAG-WT274 | Recombinant Felis domesticus Fel d 4 | E. coli | Inquiry | |
| Mus musculus | DAG-WT279 | Recombinant Mus musculus Mus m 1 | E. coli | Inquiry |