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Antigens for Allergies - IVD Raw Materials

Introduction

An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body. Such reactions are called allergies. The first time a person is exposed to an allergen, they do not usually experience a reaction. It often takes time for the immune system to build up a sensitivity to the substance. In time, the immune system learns to recognize and remember the allergen. As it does so, it starts making antibodies to attack it when exposure occurs. This buildup is called sensitization. Allergy symptoms can affect the human airways, sinuses and nasal passages, skin, and digestive system. Allergic reactions can range from mild to severe. In some severe cases, allergies can trigger a life-threatening reaction known as anaphylaxis.

IgE-Mediated Allergies

Immunoglobulin E (IgE)-mediated allergy is the most common hypersensitivity disease affecting more than 30% of the population. Exposure to even minute quantities of allergens can lead to the production of IgE antibodies in atopic individuals. This is termed allergic sensitization, which occurs mainly in early childhood. Allergen-specific IgE then binds to the high (FcεRI) and low-affinity receptors (FcεRII, also called CD23) for IgE on effector cells and antigen-presenting cells. Subsequent and repeated allergen exposure increases allergen-specific IgE levels and, by receptor cross-linking, triggers immediate release of inflammatory mediators from mast cells and basophils whereas IgE-facilitated allergen presentation perpetuates T cell–mediated allergic inflammation. Due to engagement of receptors which are highly selective for IgE, even tiny amounts of allergens can induce massive inflammation. Naturally occurring allergen-specific IgG and IgA antibodies usually recognize different epitopes on allergens compared with IgE and do not efficiently interfere with allergen-induced inflammation. However, IgG and IgA antibodies to these important IgE epitopes can be induced by allergen-specific immunotherapy or by passive immunization. These will lead to competition with IgE for binding with the allergen and prevent allergic responses. Similarly, anti-IgE treatment does the same by preventing IgE from binding to its receptor on mast cells and basophils.

Pump priming of the allergic response by allergens Fig. 1. Pump priming of the allergic response by allergens (Hannah J. Gould & Brian J. Sutton. 2008)

Types of Allergens

Many different types of allergens can trigger an allergic reaction, a very broad range of substances also can be allergens to sensitive individuals. The types of allergies including food allergies, drug allergies, insect allergies, latex allergies, mold allergies, pet allergies, pollen allergies and other allergies. An allergic reaction can be caused by any form of direct contact with the allergen—consuming food or drink, breathing in pollen, perfume or pet dander, or brushing a body part against an allergy-causing plant. In the U.S, the most common causes of food allergy are these eight foods: Milk, egg, peanut, tree nut, soy, wheat, fish, shellfish. Other common causes of serious allergy are wasp, fire ant and bee stings, penicillin, and latex.

With years of experience in production of purified allergens, Creative Diagnostics now can provide our customers various food allergens, plant allergens, animal allergens and fungal allergens with high-quality and cheaper price. These allergens can be used in animal models of IgE responses, antibody detection and biologic assays. Welcome to contact us for more details.

References

  1. Poms RE, Klein CL, Anklam E. Methods for allergen analysis in food: a review. Food Additives and Contaminants. 2004, 21(1), 1-31.
  2. WA Żukiewicz-Sobczak, P Wróblewska, P Adamczuk, P Kopczyński. Causes, symptoms and prevention of food allergy. Postepy Dermatologii I Alergologii. 2013, 30, 113-116.
  3. Hannah J. Gould & Brian J. Sutton. IgE in allergy and asthma today. Nature Reviews Immunology. 2008, 8, 205-217.
• Food allergens
Analyte Cat.No Product Name Expression System
Arachis hypogaeaDAG-WT160 Recombinant Arachis hypogaea Ara h 9.0101 [His] Insect cellsInquiry
DAG-WT162 Recombinant Arachis hypogaea Ara h 8.0101 [His] E. coliInquiry
DAG-WT159 Recombinant Arachis hypogaea Ara h 6.0101 [His] Insect cellsInquiry
DAG-WT161 Recombinant Arachis hypogaea Ara h 3.0101 [His] E. coliInquiry
Charybdis feriatusDAG-WT213 Recombinant Charybdis feriata Cha f 1 [His] E. coliInquiry
Corylus avellanaDAG-WT167 Native Corylus avellana Cor a 9 HazelnutInquiry
DAG-WT166 Recombinant Corylus avellana Cor a 8.0101 [His] Insect cellsInquiry
DAG-WT168 Recombinant Corylus avellana Cor a 14.0101 [His] Insect cellsInquiry
DAG-WT158 Recombinant Cor a 1.0401 [His] Insect cellsInquiry
Gadus callariasDAG-WT294 Recombinant Gadus callarias Gad c 1 E. coliInquiry
Gallus domesticusDAG-WT222 Recombinant Chicken Gal d 6 [His] Mammalian cellsInquiry
DAG-WT220 Recombinant Chicken Gal d 5 [His] Mammalian cellsInquiry
DAG-WT218 Recombinant Chicken Gal d 4 [His] Mammalian cellsInquiry
DAG-WT223 Recombinant Chicken Gal d 3 [His] Mammalian cellsInquiry
DAG-WT219 Recombinant Chicken Gal d 2 [His] E. coliInquiry
DAG-WT221 Recombinant Chicken Gal d 1 [His] Mammalian cellsInquiry
Glycine maxDAG-WT289 Recombinant Glycine max Gly m 4 E. coliInquiry
DAG-WT290 Recombinant Glycine max Gly m 5 E. coliInquiry
Malus domesticaDAG-WT165 Recombinant Malus domestica Mal d 3.0101 [His] Insect cellsInquiry
DAG-WT163 Recombinant Malus domestica Mal d 1.0108 [His] E. coliInquiry
DAG-WT264 Recombinant Malus Domestica Mal d 4 [His] E. coliInquiry
Mangifera indicaDAG-WT295 Recombinant Mangifera indica Man i 1 E. coliInquiry
DAG-WT296 Recombinant Mangifera indica Man i 3 E. coliInquiry
Penaeus aztecusDAG-WT164 Recombinant Penaeus aztecus Pen a 1.0101 [His] Insect cellsInquiry
Prunus persicaDAG-WT288 Recombinant Prunus persica Pru p 1 E. coliInquiry
Sesamum indicumDAG-WT291 Recombinant Sesamum indicum Ses I 1 E. coliInquiry
Triticum aestivumDAG-WT211 Recombinant allergen Tri a 19 [His] E. coliInquiry
DAG-WT169 Recombinant Triticum aestivum Tri a 14.0101 [His] Insect cellsInquiry
DAG-WT266 Recombinant Triticum Aestivum Tri a 12 [His] E. coliInquiry
• Plant allergens
Analyte Cat.No Product Name Expression System
Alnus glutinosaDAG-WT282 Recombinant Alnus glutinosa Aln g 1 E. coliInquiry
Ambrosia artemisiifoliaDAG-WT280 Recombinant Ambrosia artemisiifolia Amb a 1 E. coliInquiry
DAG-WT281 Recombinant Ambrosia artemisiifolia Amb a 2 E. coliInquiry
Artemisia vulgarisDAGA-3100 Recombinant Mugwort Art v3. [His] E. coliInquiry
DAGA-3099 Recombinant Mugwort Art v1. [His] Pichia pastorisInquiry
Betula verrucosaDAG-WT174 Recombinant Betula verrucosa Bet v 6.0101 [His] E. coliInquiry
DAG-WT173 Recombinant Betula verrucosa Bet v 4.0101 [His] Insect cellsInquiry
DAGK-008 Bet v 2.0101 (full length) [His] E. coliInquiry
DAGK-007 Bet v 1.0101 (full length) [His] Insect cellsInquiry
Carpinus betulus

DAG-WT283

Recombinant Carpinus betulus Car b 1 E. coliInquiry
Chenopodium albumDAG-WT284 Recombinant Chenopodium album Che a 1 Mammalian cellsInquiry
DAG-WT285 Recombinant Chenopodium album Che a 2 E. coliInquiry
DAG-WT286 Recombinant Chenopodium album Che a 3 E. coliInquiry
Fraxinus excelsiorDAGK-011 Fra e 1.0101 (full length) [His] Insect cellsInquiry
Humulus japonicusDAG-WT287 Recombinant Humulus japonicus Hum j 1 E. coliInquiry
Phleum pratenseDAGA-3095 Recombinant Timothy Grass Phl p 7 [His] E. coliInquiry
DAGK-006 Phl p 6.0101 (full length) [His] Insect cellsInquiry
DAGA-3093 Recombinant Timothy Grass Phl p 5a [His] E. coliInquiry
DAGA-3094 Recombinant Timothy Grass Phl p 5b [His] E. coliInquiry
DAGK-004 Phl p 2.0101 (full length) [His] Insect cellsInquiry
DAG-WT171 Recombinant Phleum pretense Phl p 12.0101 [His] Insect cellsInquiry
DAGK-003 Phl p 1.0102 (full length) [His] Insect cellsInquiry
Platanus acerifoliaDAGA-3098 Recombinant Plane Tree Pla a3. [His] E. coliInquiry
DAGA-3097 Recombinant Plane Tree Pla a1. [His] Pichia pastorisInquiry
DAG-WT265 Recombinant Platanus acerifolia Pla a 2 [His] Mammalian cellsInquiry
• Animal allergens
Analyte Cat.No Product Name Expression System
Blattella germanicaDAG-WT277 Recombinant Blattella germanica Bla g 4 E. coliInquiry
DAG-WT278 Recombinant Blattella germanica Bla g 5 E. coliInquiry
Bos domesticusDAG-WT216 Recombinant Bovine Bos d 8 [His] (Mammalian) Mammalian cellsInquiry
DAG-WT214 Recombinant Bovine Bos d 4 [His] Mammalian cellsInquiry
DAG-WT215 Recombinant Bovine Bos d 11 [His] E. coliInquiry
DAG-WT292 Recombinant Bos domesticus Bos d 2 E. coliInquiry
Canis familiarisDAGA-3086 Recombinant Dog allergen, can f5. [His] Pichia pastorisInquiry
DAGA-3088 Recombinant Dog allergen, can f1. [His] E. coliInquiry
Dermatophagoides farinaeDAGA-3090 Recombinant Dust Mite Der f2. [His] Pichia pastorisInquiry
Dermatophagoides pteronyssinusDAGA-3089 Recombinant Dust Mite Der p10 [His] E. coliInquiry
DAG-WT259 Recombinant Dust Mite Der p 6 [GST] E. coliInquiry
DAG-WT260 Recombinant Dust Mite Der p 23 [His] Mammalian cellsInquiry
DAG-WT261 Recombinant Dust Mite Der p 2 [His] E. coliInquiry
Equus caballusDAGA-3087 Recombinant Equus caballus (Equ c) 1inant [His] E. coliInquiry
Felis domesticusDAGA-3085 Recombinant Cat allergen fel d1 [His] Pichia pastorisInquiry
DAG-WT274 Recombinant Felis domesticus Fel d 4 E. coliInquiry
Mus musculusDAG-WT279 Recombinant Mus musculus Mus m 1 E. coliInquiry
• Fungal allergens
Analyte Cat.No Product Name Expression System
Aspergillus fumigatusDAG-WT275 Recombinant Aspergillus fumigatus Asp f 1 E. coliInquiry
DAG-WT276 Recombinant Aspergillus fumigatus Asp f 3 E. coliInquiry
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