Native Rheumatoid Factor (RF) Concentrate

Target

RF

Nature

Native

Bio-activity

Reported in IU/mg

Format

Liquid

Buffer

20 mM sodium phosphate, 0.5 M sodium chloride, pH 7.2.

Preservative

0.02% Proclin 300

Storage

Store at -20°C

Introduction

Rheumatoid factor (RF) is the autoantibody that was first found in rheumatoid arthritis. It is defined as an antibody against the Fc portion of IgG and different RFs can recognize different parts of the IgG-Fc. RF and IgG join to form immune complexes that contribute to the disease process. Rheumatoid factor can also be a cryoglobulin (antibody that precipitates on cooling of a blood sample); it can be either type 2 (monoclonal IgM to polyclonal IgG) or type 3 (polyclonal IgM to polyclonal IgG) cryoglobulin.

Keywords

Rheumatoid factor; RF; Rheumatoid arthritis; RA; Sjögren's syndrome; SLE