Product Overview
The recombinant Mumps Virus Nucleoprotein is expressed in insect cells.
Alternative Names
Mumps virus; MuV; Mumps virus Nucleoprotein; MuV Nucleoprotein; MuV NP; Mumps virus NP
Buffer
50 mM HEPES, pH 8.0, 150 mM NaCl, 10 % glycerol
Introduction
The mumps virus is an enveloped, single-stranded, linear negative-sense RNA virus of the genus Rubulavirus and family Paramyxovirus. The Jeryl Lynn strain of mumps virus has a genome size of 15,384 nucleotides and encodes nine proteins. Proteins involved in viral replication are the nucleoprotein (NP), phosphoprotein (P), and polymerase protein while the genomic RNA forms the ribonucleocapsid. The MuV NP encapsidates the virus genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. Mumps virus replicates by budding from the cell surface and the roughly spherical shaped virus particle, has a size ranging from 1,000 to 8,000 A. Humans are the only natural host for this virus.
Keywords
Mumps virus; MuV; Mumps virus Nucleoprotein; MuV Nucleoprotein; MuV NP; Mumps virus NP
Citations
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