Binds to pro- and latent myostatin with high specificity and inhibit activation of latent myostatin
Suitable for Inhib, ELISA
Isotype: IgG
Clonality: Monoclonal
Various conjugated forms available upon request.
Summary
Specifications
Antibody Isotype
IgG
Clone
29H4-16
Species Reactivity
Human
Immunogen
29H4-16 is a high-affinity variant of the parental 29H4 antibody.
Conjugate
Unconjugated
Applications
Application Notes
Inhib, ELISA Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
General Notes
29H4-16 is a high-affinity variant of the parental 29H4 antibody and contains four amino acids changes within the complementarity-determining regions (CDRs) of both the light and heavy chains. SRK-015, a clinical-stage mAb, is also an optimized variant of the parental 29H4 antibody. Both antibodies bind to pro- and latent myostatin with high specificity and inhibit activation of latent myostatin by preventing tolloid-mediated proteolytic cleavage.
Target
Alternative Names
Myostatin; Growth differentiation factor 8; GDF8
Citations
Publication ()
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