Mouse Sterile Filtered Serum (DAGC289)

Product Overview
The raw material used was collected from Non-Swiss Albino mice. The material for this product was processed in the USA from the blood of healthy mice that had not been inoculated with or exposed to any infectious agents. At no time during collection or processing was the material commingled with any other material of animal origin
Target
Mouse Serum
Nature
Native
Tag/Conjugate
Unconjugated
Alternative Names
Mouse Serum; Serum
Procedure
None
Purity
0.2 micron (Absolute)
Format
Amber to slightly reddish color
Concentration
Hemoglobin: <35 mg
Protein: ≥4.5 g/dl
Size
50ml, 100ml, 500ml
Buffer
pH: 6.8 - 8.2
Preservative
None
Storage
This serum is stable for ≥ 3 years when stored −20°C ± 5°C. Avoid repeated freezing and thawing.
Keywords
Mouse Serum; Serum

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References


Astragalus fasciculifolius manna; antinociceptive, anti-inflammatory and antioxidant properties in mice

IMMUNOPATHOLOGIA PERSA

Authors: Shahrani, Mehrdad; Asgharzadeh, Najmeh; Torki, Akram; Asgharian, Shirin; Lorigooini, Zahra

Introduction: Inflammation is one of the body's natural defence mechanisms alongside the cells or tissues damage due to various stimuli or infections. Pain is one of the greatest common symbols associated with different diseases. Therefore, researchers are trying to find new medications that bring patients relief with fewer side effects. Herbal medicine has been used for periods to treat acute and chronic pains. Objectives: This research evaluated the anti-inflammatory, antinociceptive and antioxidant properties of Astragalus fasciculifolius manna extract. Materials and Methods: The anti-inflammatory and antioxidant potency of the extract were determined by xylene test and ferric reducing antioxidant power assay. Results: Astragalus fasciculifolius manna extract at doses of 400, 800 and 1200 mg/kg significantly reduced acetic acid-induced writhing and formalin-induced paw licking (late and early phase) but did not affect mechanical hyperalgesia caused by heat. Moreover, naloxone failed to inhibit the antinociceptive activity of the extract. The extract of A. fasciculifolius manna also exhibited high anti-inflammatory activity against xylene induced ear edema. Treatment of mice with the extract did not improve serum antioxidant capacity. Conclusion: Results of the present research showed that A. fasciculifolius manna can prevent pain and inflammation because of the presence of high amount of saponin.

SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?

CELL DEATH DISCOVERY

Authors: Yang, Ming; Lai, Ching Lung

Since the outbreak of the new coronavirus in 2019 (SARS-CoV-2), many studies have been performed to better understand the basic mechanisms and clinical features of the disease. However, uncertainties of the underlying mechanisms of multiple organ involvement remain. A substantial proportion of severe coronavirus disease 2019 (COVID-19) patients have lymphopenia, low serum iron levels, and multiple organ involvement. Several therapeutic agents have been used for different stages of the disease, but the treatment for severe disease is still suboptimal. Understanding the mechanism of programmed cell death in COVID-19 may lead to better therapeutic strategies for these patients. On the basis of observations of basic science studies and clinical researches on COVID-19, we hypothesize that ferroptosis, a novel programmed cell death, may be an important cause of multiple organ involvement in COVID-19 and it might serve as a new treatment target. In spite of the existing findings on the involvement of ferroptosis in SARS-CoV-2 infection, there is no reported study to uncover how does ferroptosis acts in SARS-CoV-2 infection yet. Uncovering the role of ferroptosis in SARS-CoV-2 infection is essential to develop new treatment strategies for COVID-19. Intracellular cell iron depletion or new generation of ferroptosis inhibitors might be potential drug candidates for COVID-19. We hope this hypothesis may launch a new wave of studies to uncover the association of ferroptosis and SARS-CoV-2 infection in vitro and in vivo.

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