Contents of Kit
1. Polystyrene microwell ELISA plates coated with a purified antigen(12-1 x 8 wells), with holder in foil package containing desiccants
2. Negative Control, 1 vial of buffer 1.2 mL
3. Positive Control, 1 vial of buffer 1.2 mL
4. Calibrator A, 1 vial of buffer containing preservative, prediluted, 1.2 mL
5. Calibrator B, 1 vial of buffer containing preservative, prediluted, 1.2 mL
6. Calibrator C, 1 vial of buffer containing preservative, prediluted, 1.2 mL
7. Calibrator D, 1 vial of buffer containing preservative, prediluted, 1.2 mL
8. Sample Diluent, 1 vial – colored straw containing PBS-buffered saline, protein stabilizers and preservative, 50 mL.
9. Antibody Enzyme Conjugate, colored blue containing buffer, protein stabilizers and preservative, 12 mL
10. Wash Buffer (20 ×), 50 mL
11. TMB Chromogen, containing stabilizers, 10 mL
12. Stop Solution, Colorless, 10 mL
General Description
The presence of antibodies against the SSB (also known as La) antigen has been advocated as a diagnostic marker for Sjogren's syndrome (SS), an autoimmune disease characterized by inflammation of the glands leading to diminished or absent glandular secretion. SS may present as a primary disease or associate with other systemic autoimmune diseases as secondary SS. The SSB antigen is a 47 kD ribonucleic protein associated with a spectrum of small RNAs and primarily resides in the nucleus. Antibodies to the SSB antigen appear in more than 80% of patients with primary or secondary SS. Anti-SSB antibodies usually copresent with anti-SSA antibodies, however due to more common of anti-SSA antibodies in other rheumatological conditions such as systemic lupus erythematosis (SLE) and mixed connective tissue disease (MCTD). It suggests that anti-SSB is more specific for primary and secondary SS than anti-SSA.
COA
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