MMAE [HRP] (2:1) (DAG606S)

MMAE conjugated with HRP at ratio of 2:1, synthetic

Target
MMAE
Nature
Synthetic
Tag/Conjugate
HRP
Molecular Weight
47KDa
Bio-activity
Drug to HRP ratio: 2
Alternative Names
Monomethylauristatin E; Monomethyl auristatin E; MMAE
Purity
≥ 99 % of two MMAE labeled conjugates by HPLC
Format
lyophilized
Size
0.5mg, 4x0.5mg
Storage
The shelf life of this compound has not been tested, but the compound is fairly stable at RT. The compound should be stored at -20°C.
Reconstitution
Dissolve in 278 μL of deionized water to achieve 1.8 mg/mL in 1xPBS buffer containing sugar-based stabilizer (no preservative).
Introduction
This HRP-MMAE conjugate is designed with similar linker chemistry as ADC and is synthesized at Creative Diagnostics for our customers' usage in horseradish peroxidase (HRP) based assay. A long flexible PEG linker is also incorporated in the conjugate to retain the activity of HRP and MMAE binding. The final conjugate is purified to obtain a single MMAE-labeled HRP conjugate, and is lyophilized from PBS containing sugar-based stabilizer for easy shipping and storage.
Antigen Description
MMAE (monomethyl auristatin E) is an antimitotic agent that binds to tubulin and inhibits the assembly of microtubules. Mc-VC-PAB-MMAE is a thiol reactive derivative of MMAE that containing a cathepsin cleavable valine-citruline p-aminobenzylcarbamate linkage. Mc-VC-PAB-MMAE is used to prepare antibody-drug conjugates, such as brentuximab vedotin (Seattle Genetics).
Keywords
Monomethylauristatin E; Monomethyl auristatin E; MMAE

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