Product Name
MDP, muramyldipetide (Ac-muramyl-Ala-D-Glu-amide) Synthetic (vaccine adjuvant)
Subclassification
Vaccine grade-PRR Ligands-based adjuvant
Storage
Shipped at room temperature and it should be stored at room temp. DO NOT FREEZE. Stable for 6 months.
Description
Muramyl dipeptide is a peptidoglycan constituent of both Gram positive and Gram negative bacteria. It is composed of Nacetylmuramic acid linked by its lactic acid moiety to the N-terminus of an L-alanine D-isoglutamine dipeptide.
N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP, for muramyldipeptide) is the smallest immuno-adjuvant active peptidoglycan derivative capable of replacing whole mycobacteria in Freund's complete adjuvant. It can be recognized by the immune system as a PAMP (pathogen associated molecular pattern)and activate the NALP3 inflammasome which in turn leads to cytokine activation, especially IL-1α and IL-1β. uramyl dipeptide (MDP) have adjuvant activity and can be substituted for mycobacteria incomplete Freund's adjuvant. MDP is of particular interest since it is a synthetic, small, nontoxic, homogeneous molecule with therapeutic potential
MDP and its derivatives have a variety of clinical uses and therapeutic potential. Biological evaluation of MDP analogs indicated that lipophilicity of the molecule caused various important effects on biological activity by increasing adjuvant activity and decreasing pyrogenicity, which is one of the major side effects of MDP
Currently, MDP is being used an adjuvant in a subunit vaccine : gp120 recominant with MDP adjuvant (Human Immunodeficiency Virus)
Formula: C19H32N4O11
purity: ≥95% (HPLC)
Solubility: water (50 mg/ml).
Format
MDP is supplied as, sterile powder. White to off-white powder.
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